Genomic surveillance reveals multiple introductions of SARS-CoV-2 into Northern California
The COVID-19 pandemic caused by the novel coronavirus SARS-CoV-2 has spread globally, with >52,000 cases in California as of May 4, 2020. Here we investigate the genomic epidemiology of SARS-CoV-2 in Northern California from late January to mid-March 2020, using samples from 36 patients spann...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
American Association for the Advancement of Science
2020
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| _version_ | 1797086392324456448 |
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| author | Deng, X Gu, W Federman, S du Plessis, L Pybus, OG Faria, N Wang, C Yu, G Bushnell, B Pan, C-Y Guevara, H Sotomayor-Gonzalez, A Zorn, K Gopez, A Servellita, V Hsu, E Miller, S Bedford, T Greninger, AL Roychoudhury, P Starita, LM Famulare, M Chu, HY Shendure, J Jerome, KR Anderson, C Gangavarapu,K Zeller, M Spencer, E Andersen, KG MacCannell, D Paden, CR Li, Y Zhang, J Tong, S Armstrong, G Morrow, S Willis, M Matyas, BT Mase, S Kasirye, O Park, M Masinde, G Chan, C Yu, AT Chai, SJ Villarino, E Bonin, B Wadford, DA Chiu, CY |
| author_facet | Deng, X Gu, W Federman, S du Plessis, L Pybus, OG Faria, N Wang, C Yu, G Bushnell, B Pan, C-Y Guevara, H Sotomayor-Gonzalez, A Zorn, K Gopez, A Servellita, V Hsu, E Miller, S Bedford, T Greninger, AL Roychoudhury, P Starita, LM Famulare, M Chu, HY Shendure, J Jerome, KR Anderson, C Gangavarapu,K Zeller, M Spencer, E Andersen, KG MacCannell, D Paden, CR Li, Y Zhang, J Tong, S Armstrong, G Morrow, S Willis, M Matyas, BT Mase, S Kasirye, O Park, M Masinde, G Chan, C Yu, AT Chai, SJ Villarino, E Bonin, B Wadford, DA Chiu, CY |
| author_sort | Deng, X |
| collection | OXFORD |
| description | The COVID-19 pandemic caused by the novel coronavirus SARS-CoV-2 has spread globally, with >52,000 cases in California as of May 4, 2020. Here we investigate the genomic epidemiology of SARS-CoV-2 in Northern California from late January to mid-March 2020, using samples from 36 patients spanning 9 counties and the Grand Princess cruise ship. Phylogenetic analyses revealed the cryptic introduction of at least 7 different SARS-CoV-2 lineages into California, including epidemic WA1 strains associated with Washington State, with lack of a predominant lineage and limited transmission between communities. Lineages associated with outbreak clusters in 2 counties were defined by a single base substitution in the viral genome. These findings support contact tracing, social distancing, and travel restrictions to contain SARS-CoV-2 spread in California and other states. |
| first_indexed | 2024-03-07T02:21:23Z |
| format | Journal article |
| id | oxford-uuid:a40b6da3-e985-4a1a-a699-0446b8be505e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:21:23Z |
| publishDate | 2020 |
| publisher | American Association for the Advancement of Science |
| record_format | dspace |
| spelling | oxford-uuid:a40b6da3-e985-4a1a-a699-0446b8be505e2022-03-27T02:31:22ZGenomic surveillance reveals multiple introductions of SARS-CoV-2 into Northern CaliforniaJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a40b6da3-e985-4a1a-a699-0446b8be505eEnglishSymplectic ElementsAmerican Association for the Advancement of Science2020Deng, XGu, WFederman, Sdu Plessis, LPybus, OGFaria, NWang, CYu, GBushnell, BPan, C-YGuevara, HSotomayor-Gonzalez, AZorn, KGopez, AServellita, VHsu, EMiller, SBedford, TGreninger, ALRoychoudhury, PStarita, LMFamulare, MChu, HYShendure, JJerome, KRAnderson, CGangavarapu,KZeller, MSpencer, EAndersen, KGMacCannell, DPaden, CRLi, YZhang, JTong, SArmstrong, GMorrow, SWillis, MMatyas, BTMase, SKasirye, OPark, MMasinde, GChan, CYu, ATChai, SJVillarino, EBonin, BWadford, DAChiu, CYThe COVID-19 pandemic caused by the novel coronavirus SARS-CoV-2 has spread globally, with >52,000 cases in California as of May 4, 2020. Here we investigate the genomic epidemiology of SARS-CoV-2 in Northern California from late January to mid-March 2020, using samples from 36 patients spanning 9 counties and the Grand Princess cruise ship. Phylogenetic analyses revealed the cryptic introduction of at least 7 different SARS-CoV-2 lineages into California, including epidemic WA1 strains associated with Washington State, with lack of a predominant lineage and limited transmission between communities. Lineages associated with outbreak clusters in 2 counties were defined by a single base substitution in the viral genome. These findings support contact tracing, social distancing, and travel restrictions to contain SARS-CoV-2 spread in California and other states. |
| spellingShingle | Deng, X Gu, W Federman, S du Plessis, L Pybus, OG Faria, N Wang, C Yu, G Bushnell, B Pan, C-Y Guevara, H Sotomayor-Gonzalez, A Zorn, K Gopez, A Servellita, V Hsu, E Miller, S Bedford, T Greninger, AL Roychoudhury, P Starita, LM Famulare, M Chu, HY Shendure, J Jerome, KR Anderson, C Gangavarapu,K Zeller, M Spencer, E Andersen, KG MacCannell, D Paden, CR Li, Y Zhang, J Tong, S Armstrong, G Morrow, S Willis, M Matyas, BT Mase, S Kasirye, O Park, M Masinde, G Chan, C Yu, AT Chai, SJ Villarino, E Bonin, B Wadford, DA Chiu, CY Genomic surveillance reveals multiple introductions of SARS-CoV-2 into Northern California |
| title | Genomic surveillance reveals multiple introductions of SARS-CoV-2 into Northern California |
| title_full | Genomic surveillance reveals multiple introductions of SARS-CoV-2 into Northern California |
| title_fullStr | Genomic surveillance reveals multiple introductions of SARS-CoV-2 into Northern California |
| title_full_unstemmed | Genomic surveillance reveals multiple introductions of SARS-CoV-2 into Northern California |
| title_short | Genomic surveillance reveals multiple introductions of SARS-CoV-2 into Northern California |
| title_sort | genomic surveillance reveals multiple introductions of sars cov 2 into northern california |
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