Large-scale studies of the HphI insulin gene variable-number-of-tandem-repeats polymorphism in relation to Type 2 diabetes mellitus and insulin release.
AIMS/HYPOTHESIS: The class III allele of the variable-number-of-tandem-repeats polymorphism located 5' of the insulin gene (INS-VNTR) has been associated with Type 2 diabetes and altered birthweight. It has also been suggested, although inconsistently, that the class III allele plays a role in...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2004
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| _version_ | 1826288949741486080 |
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| author | Hansen, S Gjesing, A Rasmussen, S Glümer, C Urhammer, SA Andersen, G Rose, C Drivsholm, T Torekov, S Jensen, D Ekstrøm, C Borch-Johnsen, K Jørgensen, T McCarthy, M Hansen, T Pedersen, O |
| author_facet | Hansen, S Gjesing, A Rasmussen, S Glümer, C Urhammer, SA Andersen, G Rose, C Drivsholm, T Torekov, S Jensen, D Ekstrøm, C Borch-Johnsen, K Jørgensen, T McCarthy, M Hansen, T Pedersen, O |
| author_sort | Hansen, S |
| collection | OXFORD |
| description | AIMS/HYPOTHESIS: The class III allele of the variable-number-of-tandem-repeats polymorphism located 5' of the insulin gene (INS-VNTR) has been associated with Type 2 diabetes and altered birthweight. It has also been suggested, although inconsistently, that the class III allele plays a role in glucose-induced insulin response among NGT individuals. METHODS: We investigated the impact of the class III allele on Type 2 diabetes susceptibility in a case-control study involving 1462 Type 2 diabetic patients and 4931 NGT subjects. We also examined the potential impact of the class III allele in genotype-quantitative trait studies in three Danish study populations containing (i) 358 young healthy subjects; (ii) 4444 middle-aged NGT subjects, 490 subjects with IFG and 678 subjects with IGT; and (iii) 221 NGT subjects, of whom one parent had Type 2 diabetes. RESULTS: There was no difference in frequency of the class III allele or in genotype distribution between the 1462 Type 2 diabetic patients and the 4931 NGT subjects. Among the 358 young subjects the class III/III carriers had significantly reduced post-IVGTT acute serum insulin and C-peptide responses (p=0.04 and 0.03 respectively). However, among the 4444 middle-aged subjects we failed to demonstrate any association between the class III allele and post-OGTT serum insulin and C-peptide levels. CONCLUSIONS/INTERPRETATION: The class III allele of the INS-VNTR does not confer susceptibility to Type 2 diabetes or consistent alterations in glucose-induced insulin release in the examined populations, which consisted of Danish Caucasians. |
| first_indexed | 2024-03-07T02:21:27Z |
| format | Journal article |
| id | oxford-uuid:a40fea26-c667-43f4-b6f3-b086617d1130 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:21:27Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:a40fea26-c667-43f4-b6f3-b086617d11302022-03-27T02:31:23ZLarge-scale studies of the HphI insulin gene variable-number-of-tandem-repeats polymorphism in relation to Type 2 diabetes mellitus and insulin release.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a40fea26-c667-43f4-b6f3-b086617d1130EnglishSymplectic Elements at Oxford2004Hansen, SGjesing, ARasmussen, SGlümer, CUrhammer, SAAndersen, GRose, CDrivsholm, TTorekov, SJensen, DEkstrøm, CBorch-Johnsen, KJørgensen, TMcCarthy, MHansen, TPedersen, OAIMS/HYPOTHESIS: The class III allele of the variable-number-of-tandem-repeats polymorphism located 5' of the insulin gene (INS-VNTR) has been associated with Type 2 diabetes and altered birthweight. It has also been suggested, although inconsistently, that the class III allele plays a role in glucose-induced insulin response among NGT individuals. METHODS: We investigated the impact of the class III allele on Type 2 diabetes susceptibility in a case-control study involving 1462 Type 2 diabetic patients and 4931 NGT subjects. We also examined the potential impact of the class III allele in genotype-quantitative trait studies in three Danish study populations containing (i) 358 young healthy subjects; (ii) 4444 middle-aged NGT subjects, 490 subjects with IFG and 678 subjects with IGT; and (iii) 221 NGT subjects, of whom one parent had Type 2 diabetes. RESULTS: There was no difference in frequency of the class III allele or in genotype distribution between the 1462 Type 2 diabetic patients and the 4931 NGT subjects. Among the 358 young subjects the class III/III carriers had significantly reduced post-IVGTT acute serum insulin and C-peptide responses (p=0.04 and 0.03 respectively). However, among the 4444 middle-aged subjects we failed to demonstrate any association between the class III allele and post-OGTT serum insulin and C-peptide levels. CONCLUSIONS/INTERPRETATION: The class III allele of the INS-VNTR does not confer susceptibility to Type 2 diabetes or consistent alterations in glucose-induced insulin release in the examined populations, which consisted of Danish Caucasians. |
| spellingShingle | Hansen, S Gjesing, A Rasmussen, S Glümer, C Urhammer, SA Andersen, G Rose, C Drivsholm, T Torekov, S Jensen, D Ekstrøm, C Borch-Johnsen, K Jørgensen, T McCarthy, M Hansen, T Pedersen, O Large-scale studies of the HphI insulin gene variable-number-of-tandem-repeats polymorphism in relation to Type 2 diabetes mellitus and insulin release. |
| title | Large-scale studies of the HphI insulin gene variable-number-of-tandem-repeats polymorphism in relation to Type 2 diabetes mellitus and insulin release. |
| title_full | Large-scale studies of the HphI insulin gene variable-number-of-tandem-repeats polymorphism in relation to Type 2 diabetes mellitus and insulin release. |
| title_fullStr | Large-scale studies of the HphI insulin gene variable-number-of-tandem-repeats polymorphism in relation to Type 2 diabetes mellitus and insulin release. |
| title_full_unstemmed | Large-scale studies of the HphI insulin gene variable-number-of-tandem-repeats polymorphism in relation to Type 2 diabetes mellitus and insulin release. |
| title_short | Large-scale studies of the HphI insulin gene variable-number-of-tandem-repeats polymorphism in relation to Type 2 diabetes mellitus and insulin release. |
| title_sort | large scale studies of the hphi insulin gene variable number of tandem repeats polymorphism in relation to type 2 diabetes mellitus and insulin release |
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