Preferential induction of fos-like immunoreactivity in granule cells of the cochlear nucleus by acoustic stimulation in behaving rats
Neuronal activity in the cochlear nucleus was mapped in relation to acoustic stimuli that signalled a sensory-motor response, using Fos-like immunoreactivity. Rats were trained to associate an acoustic stimulus with a reward and then to discriminate between two sounds ('learning' rats; n =...
| Main Authors: | , , , , |
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| Format: | Journal article |
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Elsevier
1998
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| _version_ | 1797086400543195136 |
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| author | Carretta, D Hervé-Minvielle, A Bajo, V Villa, A Rouiller, E |
| author_facet | Carretta, D Hervé-Minvielle, A Bajo, V Villa, A Rouiller, E |
| author_sort | Carretta, D |
| collection | OXFORD |
| description | Neuronal activity in the cochlear nucleus was mapped in relation to acoustic stimuli that signalled a sensory-motor response, using Fos-like immunoreactivity. Rats were trained to associate an acoustic stimulus with a reward and then to discriminate between two sounds ('learning' rats; n = 18). The same stimuli carrying no behavioural significance were pseudo-randomly presented to 'control' rats (n = 4) to differentiate stimulus related- from learning related-activity. To establish a baseline, Fos-like immunoreactivity was determined in rats (n = 2) unexposed to acoustic stimulation. The number of Fos-positive cells was significantly increased in the rats exposed to sounds ('learning' and 'control') as compared to the non-stimulated animals. This stimulus related increase of Fos-like activity in the cochlear nucleus was most prominent in a subpopulation of small neurons, whose spatial distribution corresponds to that of the granule cells. There was also an increase in the number of Fos-positive neurons of larger size, but less prominent than for the small cells. Brief exposure to sounds (30 s) was sufficient to induce Fos-like activity. |
| first_indexed | 2024-03-07T02:21:30Z |
| format | Journal article |
| id | oxford-uuid:a413dc91-164d-44ab-b93a-8749294f8fdc |
| institution | University of Oxford |
| last_indexed | 2024-03-07T02:21:30Z |
| publishDate | 1998 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:a413dc91-164d-44ab-b93a-8749294f8fdc2022-03-27T02:31:27ZPreferential induction of fos-like immunoreactivity in granule cells of the cochlear nucleus by acoustic stimulation in behaving ratsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a413dc91-164d-44ab-b93a-8749294f8fdcSymplectic Elements at OxfordElsevier1998Carretta, DHervé-Minvielle, ABajo, VVilla, ARouiller, ENeuronal activity in the cochlear nucleus was mapped in relation to acoustic stimuli that signalled a sensory-motor response, using Fos-like immunoreactivity. Rats were trained to associate an acoustic stimulus with a reward and then to discriminate between two sounds ('learning' rats; n = 18). The same stimuli carrying no behavioural significance were pseudo-randomly presented to 'control' rats (n = 4) to differentiate stimulus related- from learning related-activity. To establish a baseline, Fos-like immunoreactivity was determined in rats (n = 2) unexposed to acoustic stimulation. The number of Fos-positive cells was significantly increased in the rats exposed to sounds ('learning' and 'control') as compared to the non-stimulated animals. This stimulus related increase of Fos-like activity in the cochlear nucleus was most prominent in a subpopulation of small neurons, whose spatial distribution corresponds to that of the granule cells. There was also an increase in the number of Fos-positive neurons of larger size, but less prominent than for the small cells. Brief exposure to sounds (30 s) was sufficient to induce Fos-like activity. |
| spellingShingle | Carretta, D Hervé-Minvielle, A Bajo, V Villa, A Rouiller, E Preferential induction of fos-like immunoreactivity in granule cells of the cochlear nucleus by acoustic stimulation in behaving rats |
| title | Preferential induction of fos-like immunoreactivity in granule cells of the cochlear nucleus by acoustic stimulation in behaving rats |
| title_full | Preferential induction of fos-like immunoreactivity in granule cells of the cochlear nucleus by acoustic stimulation in behaving rats |
| title_fullStr | Preferential induction of fos-like immunoreactivity in granule cells of the cochlear nucleus by acoustic stimulation in behaving rats |
| title_full_unstemmed | Preferential induction of fos-like immunoreactivity in granule cells of the cochlear nucleus by acoustic stimulation in behaving rats |
| title_short | Preferential induction of fos-like immunoreactivity in granule cells of the cochlear nucleus by acoustic stimulation in behaving rats |
| title_sort | preferential induction of fos like immunoreactivity in granule cells of the cochlear nucleus by acoustic stimulation in behaving rats |
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