Social determinants of ethnic disparities in SARS-CoV-2 infection: UK Biobank SARS-CoV-2 Serology Study
<p><strong>Background:</strong> The social determinants of ethnic disparities in risk of SARS-CoV-2 infection during the first wave of the pandemic in the UK remain unclear.</p> <p><strong>Methods:</strong> In May 2020, a total of 20 195 adults were recruit...
| Κύριοι συγγραφείς: | , , , , , , , , , , , , , , , , , , |
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| Μορφή: | Journal article |
| Γλώσσα: | English |
| Έκδοση: |
BMJ Publishing Group
2023
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| _version_ | 1826313302573056000 |
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| author | Omiyale, W Holliday, JC Doherty, N Callen, H Wood, N Horn, E Burnett, F Young, A Lewington, S Fry, D Bešević, J Conroy, M Sheard, S Feng, Q Welsh, S Effingham, M Young, A Collins, R Lacey, B Allen, N |
| author_facet | Omiyale, W Holliday, JC Doherty, N Callen, H Wood, N Horn, E Burnett, F Young, A Lewington, S Fry, D Bešević, J Conroy, M Sheard, S Feng, Q Welsh, S Effingham, M Young, A Collins, R Lacey, B Allen, N |
| author_sort | Omiyale, W |
| collection | OXFORD |
| description | <p><strong>Background:</strong> The social determinants of ethnic disparities in risk of SARS-CoV-2 infection during the first wave of the pandemic in the UK remain unclear.</p>
<p><strong>Methods:</strong> In May 2020, a total of 20 195 adults were recruited from the general population into the UK Biobank SARS-CoV-2 Serology Study. Between mid-May and mid-November 2020, participants provided monthly blood samples. At the end of the study, participants completed a questionnaire on social factors during different periods of the pandemic. Logistic regression yielded ORs for the association between ethnicity and SARS-CoV-2 immunoglobulin G antibodies (indicating prior infection) using blood samples collected in July 2020, immediately after the first wave.</p>
<p><strong>Results:</strong> After exclusions, 14 571 participants (mean age 56; 58% women) returned a blood sample in July, of whom 997 (7%) had SARS-CoV-2 antibodies. Seropositivity was strongly related to ethnicity: compared with those of White ethnicity, ORs (adjusted for age and sex) for Black, South Asian, Chinese, Mixed and Other ethnic groups were 2.66 (95% CI 1.94–3.60), 1.66 (1.15–2.34), 0.99 (0.42–1.99), 1.42 (1.03–1.91) and 1.79 (1.27–2.47), respectively. Additional adjustment for social factors reduced the overall likelihood ratio statistics for ethnicity by two-thirds (67%; mostly from occupational factors and UK region of residence); more precise measurement of social factors may have further reduced the association.</p>
<p><strong>Conclusions:</strong> This study identifies social factors that are likely to account for much of the ethnic disparities in SARS-CoV-2 infection during the first wave in the UK, and highlights the particular relevance of occupation and residential region in the pathway between ethnicity and SARS-CoV-2 infection.</p> |
| first_indexed | 2024-03-07T08:15:58Z |
| format | Journal article |
| id | oxford-uuid:a416c75e-5bc8-4e65-9778-c1f47d06aef0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-09-25T04:10:54Z |
| publishDate | 2023 |
| publisher | BMJ Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:a416c75e-5bc8-4e65-9778-c1f47d06aef02024-06-19T10:18:35ZSocial determinants of ethnic disparities in SARS-CoV-2 infection: UK Biobank SARS-CoV-2 Serology StudyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a416c75e-5bc8-4e65-9778-c1f47d06aef0EnglishSymplectic ElementsBMJ Publishing Group2023Omiyale, WHolliday, JCDoherty, NCallen, HWood, NHorn, EBurnett, FYoung, ALewington, SFry, DBešević, JConroy, MSheard, SFeng, QWelsh, SEffingham, MYoung, ACollins, RLacey, BAllen, N<p><strong>Background:</strong> The social determinants of ethnic disparities in risk of SARS-CoV-2 infection during the first wave of the pandemic in the UK remain unclear.</p> <p><strong>Methods:</strong> In May 2020, a total of 20 195 adults were recruited from the general population into the UK Biobank SARS-CoV-2 Serology Study. Between mid-May and mid-November 2020, participants provided monthly blood samples. At the end of the study, participants completed a questionnaire on social factors during different periods of the pandemic. Logistic regression yielded ORs for the association between ethnicity and SARS-CoV-2 immunoglobulin G antibodies (indicating prior infection) using blood samples collected in July 2020, immediately after the first wave.</p> <p><strong>Results:</strong> After exclusions, 14 571 participants (mean age 56; 58% women) returned a blood sample in July, of whom 997 (7%) had SARS-CoV-2 antibodies. Seropositivity was strongly related to ethnicity: compared with those of White ethnicity, ORs (adjusted for age and sex) for Black, South Asian, Chinese, Mixed and Other ethnic groups were 2.66 (95% CI 1.94–3.60), 1.66 (1.15–2.34), 0.99 (0.42–1.99), 1.42 (1.03–1.91) and 1.79 (1.27–2.47), respectively. Additional adjustment for social factors reduced the overall likelihood ratio statistics for ethnicity by two-thirds (67%; mostly from occupational factors and UK region of residence); more precise measurement of social factors may have further reduced the association.</p> <p><strong>Conclusions:</strong> This study identifies social factors that are likely to account for much of the ethnic disparities in SARS-CoV-2 infection during the first wave in the UK, and highlights the particular relevance of occupation and residential region in the pathway between ethnicity and SARS-CoV-2 infection.</p> |
| spellingShingle | Omiyale, W Holliday, JC Doherty, N Callen, H Wood, N Horn, E Burnett, F Young, A Lewington, S Fry, D Bešević, J Conroy, M Sheard, S Feng, Q Welsh, S Effingham, M Young, A Collins, R Lacey, B Allen, N Social determinants of ethnic disparities in SARS-CoV-2 infection: UK Biobank SARS-CoV-2 Serology Study |
| title | Social determinants of ethnic disparities in SARS-CoV-2 infection: UK Biobank SARS-CoV-2 Serology Study |
| title_full | Social determinants of ethnic disparities in SARS-CoV-2 infection: UK Biobank SARS-CoV-2 Serology Study |
| title_fullStr | Social determinants of ethnic disparities in SARS-CoV-2 infection: UK Biobank SARS-CoV-2 Serology Study |
| title_full_unstemmed | Social determinants of ethnic disparities in SARS-CoV-2 infection: UK Biobank SARS-CoV-2 Serology Study |
| title_short | Social determinants of ethnic disparities in SARS-CoV-2 infection: UK Biobank SARS-CoV-2 Serology Study |
| title_sort | social determinants of ethnic disparities in sars cov 2 infection uk biobank sars cov 2 serology study |
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