In vivo characteristics of human immunodeficiency virus type 1 intersubtype recombination: Determination of hot spots and correlation with sequence similarity
Recombination plays a pivotal role in the evolutionary process of many different virus species, including retroviruses. Analysis of all human immunodeficiency virus type 1 (HIV-1) intersubtype recombinants revealed that they are more complex than described initially. Recombination frequency is highe...
| Główni autorzy: | , , , , , |
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| Format: | Journal article |
| Język: | English |
| Wydane: |
2003
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| _version_ | 1826288958544281600 |
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| author | Magiorkinis, G Paraskevis, D Vandamme, A Magiokinis, E Sypsa, V Hatzakis, A |
| author_facet | Magiorkinis, G Paraskevis, D Vandamme, A Magiokinis, E Sypsa, V Hatzakis, A |
| author_sort | Magiorkinis, G |
| collection | OXFORD |
| description | Recombination plays a pivotal role in the evolutionary process of many different virus species, including retroviruses. Analysis of all human immunodeficiency virus type 1 (HIV-1) intersubtype recombinants revealed that they are more complex than described initially. Recombination frequency is higher within certain genomic regions, such as partial reverse transcriptase (RT), vif/vpr, the first exons of tat/rev, vpu and gp41. A direct correlation was observed between recombination frequency and sequence similarity across the HIV-1 genome, indicating that sufficient sequence similarity is required upstream of the recombination breakpoint. This finding suggests that recombination in vivo may occur preferentially during reverse transcription through the strand displacement-assimilation model rather than the copy-choice model. |
| first_indexed | 2024-03-07T02:21:35Z |
| format | Journal article |
| id | oxford-uuid:a41a7c63-c16f-4ad8-96b1-1c75a8a39997 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:21:35Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | oxford-uuid:a41a7c63-c16f-4ad8-96b1-1c75a8a399972022-03-27T02:31:38ZIn vivo characteristics of human immunodeficiency virus type 1 intersubtype recombination: Determination of hot spots and correlation with sequence similarityJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a41a7c63-c16f-4ad8-96b1-1c75a8a39997EnglishSymplectic Elements at Oxford2003Magiorkinis, GParaskevis, DVandamme, AMagiokinis, ESypsa, VHatzakis, ARecombination plays a pivotal role in the evolutionary process of many different virus species, including retroviruses. Analysis of all human immunodeficiency virus type 1 (HIV-1) intersubtype recombinants revealed that they are more complex than described initially. Recombination frequency is higher within certain genomic regions, such as partial reverse transcriptase (RT), vif/vpr, the first exons of tat/rev, vpu and gp41. A direct correlation was observed between recombination frequency and sequence similarity across the HIV-1 genome, indicating that sufficient sequence similarity is required upstream of the recombination breakpoint. This finding suggests that recombination in vivo may occur preferentially during reverse transcription through the strand displacement-assimilation model rather than the copy-choice model. |
| spellingShingle | Magiorkinis, G Paraskevis, D Vandamme, A Magiokinis, E Sypsa, V Hatzakis, A In vivo characteristics of human immunodeficiency virus type 1 intersubtype recombination: Determination of hot spots and correlation with sequence similarity |
| title | In vivo characteristics of human immunodeficiency virus type 1 intersubtype recombination: Determination of hot spots and correlation with sequence similarity |
| title_full | In vivo characteristics of human immunodeficiency virus type 1 intersubtype recombination: Determination of hot spots and correlation with sequence similarity |
| title_fullStr | In vivo characteristics of human immunodeficiency virus type 1 intersubtype recombination: Determination of hot spots and correlation with sequence similarity |
| title_full_unstemmed | In vivo characteristics of human immunodeficiency virus type 1 intersubtype recombination: Determination of hot spots and correlation with sequence similarity |
| title_short | In vivo characteristics of human immunodeficiency virus type 1 intersubtype recombination: Determination of hot spots and correlation with sequence similarity |
| title_sort | in vivo characteristics of human immunodeficiency virus type 1 intersubtype recombination determination of hot spots and correlation with sequence similarity |
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