Model scenarios for switch-like mitotic transitions.
To facilitate rapid accumulation of Cdk1-phosphorylated substrate proteins, the Cdk1 counter-acting phosphatase, PP2A-B55 is inhibited during M phase by stoichiometric inhibitors (ENSA and Arpp19). These inhibitors are activated when phosphorylated by Cdk1-activated Greatwall-kinase. Recent experime...
| Auteurs principaux: | , |
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| Format: | Journal article |
| Langue: | English |
| Publié: |
Elsevier
2015
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