Mapping analyses to estimate health utilities based on responses to the OM8-30 Otitis Media Questionnaire.
PURPOSE: To investigate the statistical relationship between the OM8-30 health-related quality of life measure for children with otitis media with effusion (OME) and measures of health utility (Health Utilities Index [HUI] Mark 3 and Mark 2) and to develop models to estimate HUI3 and HUI2 health uti...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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2010
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| _version_ | 1826288978399068160 |
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| author | Dakin, H Petrou, S Haggard, M Benge, S Williamson, I |
| author_facet | Dakin, H Petrou, S Haggard, M Benge, S Williamson, I |
| author_sort | Dakin, H |
| collection | OXFORD |
| description | PURPOSE: To investigate the statistical relationship between the OM8-30 health-related quality of life measure for children with otitis media with effusion (OME) and measures of health utility (Health Utilities Index [HUI] Mark 3 and Mark 2) and to develop models to estimate HUI3 and HUI2 health utilities from OM8-30 scores. METHODS: A placebo-controlled, randomised trial (GNOME) evaluating intranasal mometasone in 217 children with OME provided concurrent responses to OM8-30 and HUI at three time points. Ordinary least squares (OLS), generalised linear models and two-step regression analyses were used to predict HUI3 and HUI2 utilities based on OM8-30 facet and domain scores. RESULTS: OLS models including all nine OM8-30 facets with or without predicted hearing level (HL) produced the best predictions of HUI3 utilities (mean absolute error: 0.134 with HL and 0.132 without; R(2): 0.63 with HL and 0.596 without). An OLS model predicting HUI3 utilities based on the two OM8-30 domain scores, reported hearing difficulties, predicted HL, age and sex also produced accurate predictions. CONCLUSION: Regression equations predicting HUI3 and HUI2 utilities based on OM8-30 facet and domain scores have been developed. These provide an empirical basis for estimating quality-adjusted life years (QALYs) for interventions in children with OME. |
| first_indexed | 2024-03-07T02:21:53Z |
| format | Journal article |
| id | oxford-uuid:a4374352-70f4-4474-a5b4-dc1b606a804d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:21:53Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:a4374352-70f4-4474-a5b4-dc1b606a804d2022-03-27T02:32:17ZMapping analyses to estimate health utilities based on responses to the OM8-30 Otitis Media Questionnaire.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a4374352-70f4-4474-a5b4-dc1b606a804dEnglishSymplectic Elements at Oxford2010Dakin, HPetrou, SHaggard, MBenge, SWilliamson, IPURPOSE: To investigate the statistical relationship between the OM8-30 health-related quality of life measure for children with otitis media with effusion (OME) and measures of health utility (Health Utilities Index [HUI] Mark 3 and Mark 2) and to develop models to estimate HUI3 and HUI2 health utilities from OM8-30 scores. METHODS: A placebo-controlled, randomised trial (GNOME) evaluating intranasal mometasone in 217 children with OME provided concurrent responses to OM8-30 and HUI at three time points. Ordinary least squares (OLS), generalised linear models and two-step regression analyses were used to predict HUI3 and HUI2 utilities based on OM8-30 facet and domain scores. RESULTS: OLS models including all nine OM8-30 facets with or without predicted hearing level (HL) produced the best predictions of HUI3 utilities (mean absolute error: 0.134 with HL and 0.132 without; R(2): 0.63 with HL and 0.596 without). An OLS model predicting HUI3 utilities based on the two OM8-30 domain scores, reported hearing difficulties, predicted HL, age and sex also produced accurate predictions. CONCLUSION: Regression equations predicting HUI3 and HUI2 utilities based on OM8-30 facet and domain scores have been developed. These provide an empirical basis for estimating quality-adjusted life years (QALYs) for interventions in children with OME. |
| spellingShingle | Dakin, H Petrou, S Haggard, M Benge, S Williamson, I Mapping analyses to estimate health utilities based on responses to the OM8-30 Otitis Media Questionnaire. |
| title | Mapping analyses to estimate health utilities based on responses to the OM8-30 Otitis Media Questionnaire. |
| title_full | Mapping analyses to estimate health utilities based on responses to the OM8-30 Otitis Media Questionnaire. |
| title_fullStr | Mapping analyses to estimate health utilities based on responses to the OM8-30 Otitis Media Questionnaire. |
| title_full_unstemmed | Mapping analyses to estimate health utilities based on responses to the OM8-30 Otitis Media Questionnaire. |
| title_short | Mapping analyses to estimate health utilities based on responses to the OM8-30 Otitis Media Questionnaire. |
| title_sort | mapping analyses to estimate health utilities based on responses to the om8 30 otitis media questionnaire |
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