Selective bisubstrate inhibitors with sub-nanomolar affinity for protein kinase Pim-1.
Potent and selective: The unique nature of the ATP binding pocket structure of Pim family protein kinases (PKs) was used for the development of bisubstrate inhibitors and a fluorescent probe with sub-nanomolar affinity. Conjugates of arginine-rich peptides with two ATP mimetic scaffolds were synthes...
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Bibliographic Details
| Main Authors: |
Ekambaram, R,
Enkvist, E,
Vaasa, A,
Kasari, M,
Raidaru, G,
Knapp, S,
Uri, A |
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| Format: | Journal article
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| Language: | English |
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| Published: |
2013
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