Comparative enzymology of 11 beta -hydroxysteroid dehydrogenase type 1 from glucocorticoid resistant (Guinea pig) versus sensitive (human) species.
Type 1 11 beta-hydroxysteroid dehydrogenase constitutes a prereceptor control mechanism through its ability to reduce dehydroglucocorticoids to the receptor ligands cortisol and corticosterone in vivo. We compared kinetic characteristics of the human and guinea pig 11 beta-hydroxysteroid dehydrogena...
Main Authors: | Shafqat, N, Elleby, B, Svensson, S, Shafqat, J, Jörnvall, H, Abrahmsen, L, Oppermann, U |
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Format: | Journal article |
Sprog: | English |
Udgivet: |
2003
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Lignende værker
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Human and rodent type 1 11beta-hydroxysteroid dehydrogenases are 7beta-hydroxycholesterol dehydrogenases involved in oxysterol metabolism.
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