Optogenetic control of cells and circuits.
The absorption of light by bound or diffusible chromophores causes conformational rearrangements in natural and artificial photoreceptor proteins. These rearrangements are coupled to the opening or closing of ion transport pathways, the association or dissociation of binding partners, the enhancemen...
| Tác giả chính: | |
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| Định dạng: | Journal article |
| Ngôn ngữ: | English |
| Được phát hành: |
2011
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| _version_ | 1826289017458524160 |
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| author | Miesenböck, G |
| author_facet | Miesenböck, G |
| author_sort | Miesenböck, G |
| collection | OXFORD |
| description | The absorption of light by bound or diffusible chromophores causes conformational rearrangements in natural and artificial photoreceptor proteins. These rearrangements are coupled to the opening or closing of ion transport pathways, the association or dissociation of binding partners, the enhancement or suppression of catalytic activity, or the transcription or repression of genetic information. Illumination of cells, tissues, or organisms engineered genetically to express photoreceptor proteins can thus be used to perturb biochemical and electrical signaling with exquisite cellular and molecular specificity. First demonstrated in 2002, this principle of optogenetic control has had a profound impact on neuroscience, where it provides a direct and stringent means of probing the organization of neural circuits and of identifying the neural substrates of behavior. The impact of optogenetic control is also beginning to be felt in other areas of cell and organismal biology. |
| first_indexed | 2024-03-07T02:22:29Z |
| format | Journal article |
| id | oxford-uuid:a46b2408-dece-4ac1-a7ae-1b1e3f77bf3e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:22:29Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:a46b2408-dece-4ac1-a7ae-1b1e3f77bf3e2022-03-27T02:33:42ZOptogenetic control of cells and circuits.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a46b2408-dece-4ac1-a7ae-1b1e3f77bf3eEnglishSymplectic Elements at Oxford2011Miesenböck, GThe absorption of light by bound or diffusible chromophores causes conformational rearrangements in natural and artificial photoreceptor proteins. These rearrangements are coupled to the opening or closing of ion transport pathways, the association or dissociation of binding partners, the enhancement or suppression of catalytic activity, or the transcription or repression of genetic information. Illumination of cells, tissues, or organisms engineered genetically to express photoreceptor proteins can thus be used to perturb biochemical and electrical signaling with exquisite cellular and molecular specificity. First demonstrated in 2002, this principle of optogenetic control has had a profound impact on neuroscience, where it provides a direct and stringent means of probing the organization of neural circuits and of identifying the neural substrates of behavior. The impact of optogenetic control is also beginning to be felt in other areas of cell and organismal biology. |
| spellingShingle | Miesenböck, G Optogenetic control of cells and circuits. |
| title | Optogenetic control of cells and circuits. |
| title_full | Optogenetic control of cells and circuits. |
| title_fullStr | Optogenetic control of cells and circuits. |
| title_full_unstemmed | Optogenetic control of cells and circuits. |
| title_short | Optogenetic control of cells and circuits. |
| title_sort | optogenetic control of cells and circuits |
| work_keys_str_mv | AT miesenbockg optogeneticcontrolofcellsandcircuits |