The role of muscle-specific tyrosine kinase (MuSK) and mystery of MuSK myasthenia gravis
MuSK myasthenia gravis is a rare, severe autoimmune disease of the neuromuscular junction, only identified in 2001, with unclear pathogenic mechanisms. In this review we describe the clinical aspects that distinguish MuSK MG from AChR MG, review what is known about the role of MuSK in the developmen...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2014
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| _version_ | 1797086504876507136 |
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| author | Koneczny, I Cossins, J Vincent, A |
| author_facet | Koneczny, I Cossins, J Vincent, A |
| author_sort | Koneczny, I |
| collection | OXFORD |
| description | MuSK myasthenia gravis is a rare, severe autoimmune disease of the neuromuscular junction, only identified in 2001, with unclear pathogenic mechanisms. In this review we describe the clinical aspects that distinguish MuSK MG from AChR MG, review what is known about the role of MuSK in the development and function of the neuromuscular junction, and discuss the data that address how the antibodies to MuSK lead to neuromuscular transmission failure. © 2013 Anatomical Society. |
| first_indexed | 2024-03-07T02:23:01Z |
| format | Journal article |
| id | oxford-uuid:a49b52e1-214d-4c05-96bb-7cc358dcb949 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:23:01Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | oxford-uuid:a49b52e1-214d-4c05-96bb-7cc358dcb9492022-03-27T02:34:57ZThe role of muscle-specific tyrosine kinase (MuSK) and mystery of MuSK myasthenia gravisJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a49b52e1-214d-4c05-96bb-7cc358dcb949EnglishSymplectic Elements at Oxford2014Koneczny, ICossins, JVincent, AMuSK myasthenia gravis is a rare, severe autoimmune disease of the neuromuscular junction, only identified in 2001, with unclear pathogenic mechanisms. In this review we describe the clinical aspects that distinguish MuSK MG from AChR MG, review what is known about the role of MuSK in the development and function of the neuromuscular junction, and discuss the data that address how the antibodies to MuSK lead to neuromuscular transmission failure. © 2013 Anatomical Society. |
| spellingShingle | Koneczny, I Cossins, J Vincent, A The role of muscle-specific tyrosine kinase (MuSK) and mystery of MuSK myasthenia gravis |
| title | The role of muscle-specific tyrosine kinase (MuSK) and mystery of MuSK myasthenia gravis |
| title_full | The role of muscle-specific tyrosine kinase (MuSK) and mystery of MuSK myasthenia gravis |
| title_fullStr | The role of muscle-specific tyrosine kinase (MuSK) and mystery of MuSK myasthenia gravis |
| title_full_unstemmed | The role of muscle-specific tyrosine kinase (MuSK) and mystery of MuSK myasthenia gravis |
| title_short | The role of muscle-specific tyrosine kinase (MuSK) and mystery of MuSK myasthenia gravis |
| title_sort | role of muscle specific tyrosine kinase musk and mystery of musk myasthenia gravis |
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