Integration from proteins to organs: the IUPS Physiome Project
The IUPS Physiome Project is an internationally collaborative open source project intended to provide a public domain framework for computational physiology, including the development of modeling standards, computational tools and web-accessible databases of models of structure and function at all s...
| প্রধান লেখক: | , , , |
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| বিন্যাস: | Journal article |
| প্রকাশিত: |
2005
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| _version_ | 1826289066724818944 |
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| author | Hunter, P Smith, N Fernandez, J Tawhai, M |
| author_facet | Hunter, P Smith, N Fernandez, J Tawhai, M |
| author_sort | Hunter, P |
| collection | OXFORD |
| description | The IUPS Physiome Project is an internationally collaborative open source project intended to provide a public domain framework for computational physiology, including the development of modeling standards, computational tools and web-accessible databases of models of structure and function at all spatial scales and across all organ systems. Here, we illustrate the application of this multi-scale modeling approach to three organ systems: the heart, the lungs and the musculo-skeletal system, and in each case we show how the organ level models incorporate tissue and cell-level physiology. Although the computational physiology framework presented here does not yet incorporate models of ageing processes, the model-based approach is certainly capable of describing ageing and disease-related processes both via parameter changes within the models of normal physiological processes and via models of additional processes added to the framework. |
| first_indexed | 2024-03-07T02:23:15Z |
| format | Journal article |
| id | oxford-uuid:a4ae8652-8382-4d2c-aa6c-2fe4c46e2098 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T02:23:15Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | oxford-uuid:a4ae8652-8382-4d2c-aa6c-2fe4c46e20982022-03-27T02:35:29ZIntegration from proteins to organs: the IUPS Physiome ProjectJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a4ae8652-8382-4d2c-aa6c-2fe4c46e2098Department of Computer Science2005Hunter, PSmith, NFernandez, JTawhai, MThe IUPS Physiome Project is an internationally collaborative open source project intended to provide a public domain framework for computational physiology, including the development of modeling standards, computational tools and web-accessible databases of models of structure and function at all spatial scales and across all organ systems. Here, we illustrate the application of this multi-scale modeling approach to three organ systems: the heart, the lungs and the musculo-skeletal system, and in each case we show how the organ level models incorporate tissue and cell-level physiology. Although the computational physiology framework presented here does not yet incorporate models of ageing processes, the model-based approach is certainly capable of describing ageing and disease-related processes both via parameter changes within the models of normal physiological processes and via models of additional processes added to the framework. |
| spellingShingle | Hunter, P Smith, N Fernandez, J Tawhai, M Integration from proteins to organs: the IUPS Physiome Project |
| title | Integration from proteins to organs: the IUPS Physiome Project |
| title_full | Integration from proteins to organs: the IUPS Physiome Project |
| title_fullStr | Integration from proteins to organs: the IUPS Physiome Project |
| title_full_unstemmed | Integration from proteins to organs: the IUPS Physiome Project |
| title_short | Integration from proteins to organs: the IUPS Physiome Project |
| title_sort | integration from proteins to organs the iups physiome project |
| work_keys_str_mv | AT hunterp integrationfromproteinstoorganstheiupsphysiomeproject AT smithn integrationfromproteinstoorganstheiupsphysiomeproject AT fernandezj integrationfromproteinstoorganstheiupsphysiomeproject AT tawhaim integrationfromproteinstoorganstheiupsphysiomeproject |