Pharmacokinetics of TKM-130803 in Sierra Leonean patients with Ebola virus disease: Plasma concentrations exceed target levels, with drug accumulation in the most severe patients

Pharmacokinetics of TKM-130803 in Sierra Leonean patients with Ebola virus disease: Plasma concentrations exceed target levels, with drug accumulation in the most severe patients

<p><strong>Background:</strong><br /> TKM-130803 is a specific anti-EBOV therapeutic comprised of two small interfering RNAs (siRNA) siLpol-2 and siVP35-2. The pharmacokinetics (PK) of these siRNAs was defined in Ebola virus disease (EVD) patients, with reference to efficacy...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Scott, JT, Sharma, R, Meredith, LW, Dunning, J, Moore, CE, Sahr, F, Ward, S, Goodfellow, I, Horby, P
Άλλοι συγγραφείς: RAPIDE-TKM Trial Team
Μορφή: Journal article
Γλώσσα:English
Έκδοση: Elsevier 2020

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