Architecture of eukaryotic mRNA 3'-end processing machinery

Architecture of eukaryotic mRNA 3'-end processing machinery

Newly transcribed eukaryotic pre-mRNAs are processed at their 3'-ends by the ~1 MDa multiprotein cleavage and polyadenylation factor (CPF). CPF cleaves pre-mRNAs, adds a poly(A) tail and triggers transcription termination but it is unclear how its different enzymes are coordinated and assembled...

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Bibliographic Details
Main Authors: Casañal, A, Kumar, A, Hill, C, Easter, A, Emsley, P, Degliesposti, G, Gordiyenko, Y, Santhanam, B, Wolf, J, Wiederhold, K, Dornan, G, Skehel, M, Robinson, C, Passmore, L
Format: Journal article
Language:English
Published: American Association for the Advancement of Science 2017

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