Maternal spindle transfer overcomes embryo developmental arrest caused by ooplasmic defects in mice

The developmental potential of early embryos is mainly dictated by the quality of the oocyte. Here, we explore the utility of the maternal spindle transfer (MST) technique as a reproductive approach to enhance oocyte developmental competence. Our proof-of-concept experiments show that replacement of...

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Detalhes bibliográficos
Main Authors: Costa-Borges, N, Spath, K, Miguel-Escalada, I, Mestres, E, Balmaseda, R, Serafín, A, Garcia-Jiménez, M, Vanrell, I, González, J, Rink, K, Wells, D, Calderón, G
Formato: Journal article
Idioma:English
Publicado em: eLife Sciences Publications 2020