Prostate-specific antigen-activated thapsigargin prodrug as targeted therapy for prostate cancer.

Prostate-specific antigen-activated thapsigargin prodrug as targeted therapy for prostate cancer.

BACKGROUND: Standard anti-proliferative chemotherapy is relatively ineffective against slowly proliferating androgen-independent prostate cancer cells within metastatic sites. In contrast, the lipophilic cytotoxin thapsigargin, which causes apoptosis by disrupting intracellular free Ca2+ levels, is...

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Bibliographic Details
Main Authors:	Denmeade, SR, Jakobsen, C, Janssen, S, Khan, SR, Garrett, E, Lilja, H, Christensen, S, Isaacs, J
Format:	Journal article
Language:	English
Published:	2003

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