Exposure to multiple parasites is associated with the prevalence of active convulsive epilepsy in sub-Saharan Africa
BACKGROUND: Epilepsy is common in developing countries, and it is often associated with parasitic infections. We investigated the relationship between exposure to parasitic infections, particularly multiple infections and active convulsive epilepsy (ACE), in five sites across sub-Saharan Africa. MET...
| Asıl Yazarlar: | , , , , , , , , , , , , , , , , |
|---|---|
| Materyal Türü: | Journal article |
| Dil: | English |
| Baskı/Yayın Bilgisi: |
Public Library of Science
2014
|
| _version_ | 1826289136184590336 |
|---|---|
| author | Kamuyu, G Bottomley, C Mageto, J Lowe, B Wilkins, P Noh, J Nutman, T Ngugi, A Odhiambo, R Wagner, R Kakooza-Mwesige, A Owusu-Agyei, S Ae-Ngibise, K Masanja, H Osier, F Odermatt, P Newton, C |
| author_facet | Kamuyu, G Bottomley, C Mageto, J Lowe, B Wilkins, P Noh, J Nutman, T Ngugi, A Odhiambo, R Wagner, R Kakooza-Mwesige, A Owusu-Agyei, S Ae-Ngibise, K Masanja, H Osier, F Odermatt, P Newton, C |
| author_sort | Kamuyu, G |
| collection | OXFORD |
| description | BACKGROUND: Epilepsy is common in developing countries, and it is often associated with parasitic infections. We investigated the relationship between exposure to parasitic infections, particularly multiple infections and active convulsive epilepsy (ACE), in five sites across sub-Saharan Africa. METHODS AND FINDINGS: A case-control design that matched on age and location was used. Blood samples were collected from 986 prevalent cases and 1,313 age-matched community controls and tested for presence of antibodies to Onchocerca volvulus, Toxocara canis, Toxoplasma gondii, Plasmodium falciparum, Taenia solium and HIV. Exposure (seropositivity) to Onchocerca volvulus (OR = 1.98; 95%CI: 1.52-2.58, p<0.001), Toxocara canis (OR = 1.52; 95%CI: 1.23-1.87, p<0.001), Toxoplasma gondii (OR = 1.28; 95%CI: 1.04-1.56, p = 0.018) and higher antibody levels (top tertile) to Toxocara canis (OR = 1.70; 95%CI: 1.30-2.24, p<0.001) were associated with an increased prevalence of ACE. Exposure to multiple infections was common (73.8% of cases and 65.5% of controls had been exposed to two or more infections), and for T. gondii and O. volvulus co-infection, their combined effect on the prevalence of ACE, as determined by the relative excess risk due to interaction (RERI), was more than additive (T. gondii and O. volvulus, RERI = 1.19). The prevalence of T. solium antibodies was low (2.8% of cases and 2.2% of controls) and was not associated with ACE in the study areas. CONCLUSION: This study investigates how the degree of exposure to parasites and multiple parasitic infections are associated with ACE and may explain conflicting results obtained when only seropositivity is considered. The findings from this study should be further validated. |
| first_indexed | 2024-03-07T02:24:18Z |
| format | Journal article |
| id | oxford-uuid:a50e46f9-5ae9-44d9-8ec9-e3fb636a0a9d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:24:18Z |
| publishDate | 2014 |
| publisher | Public Library of Science |
| record_format | dspace |
| spelling | oxford-uuid:a50e46f9-5ae9-44d9-8ec9-e3fb636a0a9d2022-03-27T02:37:51ZExposure to multiple parasites is associated with the prevalence of active convulsive epilepsy in sub-Saharan AfricaJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a50e46f9-5ae9-44d9-8ec9-e3fb636a0a9dEnglishSymplectic Elements at OxfordPublic Library of Science2014Kamuyu, GBottomley, CMageto, JLowe, BWilkins, PNoh, JNutman, TNgugi, AOdhiambo, RWagner, RKakooza-Mwesige, AOwusu-Agyei, SAe-Ngibise, KMasanja, HOsier, FOdermatt, PNewton, CBACKGROUND: Epilepsy is common in developing countries, and it is often associated with parasitic infections. We investigated the relationship between exposure to parasitic infections, particularly multiple infections and active convulsive epilepsy (ACE), in five sites across sub-Saharan Africa. METHODS AND FINDINGS: A case-control design that matched on age and location was used. Blood samples were collected from 986 prevalent cases and 1,313 age-matched community controls and tested for presence of antibodies to Onchocerca volvulus, Toxocara canis, Toxoplasma gondii, Plasmodium falciparum, Taenia solium and HIV. Exposure (seropositivity) to Onchocerca volvulus (OR = 1.98; 95%CI: 1.52-2.58, p<0.001), Toxocara canis (OR = 1.52; 95%CI: 1.23-1.87, p<0.001), Toxoplasma gondii (OR = 1.28; 95%CI: 1.04-1.56, p = 0.018) and higher antibody levels (top tertile) to Toxocara canis (OR = 1.70; 95%CI: 1.30-2.24, p<0.001) were associated with an increased prevalence of ACE. Exposure to multiple infections was common (73.8% of cases and 65.5% of controls had been exposed to two or more infections), and for T. gondii and O. volvulus co-infection, their combined effect on the prevalence of ACE, as determined by the relative excess risk due to interaction (RERI), was more than additive (T. gondii and O. volvulus, RERI = 1.19). The prevalence of T. solium antibodies was low (2.8% of cases and 2.2% of controls) and was not associated with ACE in the study areas. CONCLUSION: This study investigates how the degree of exposure to parasites and multiple parasitic infections are associated with ACE and may explain conflicting results obtained when only seropositivity is considered. The findings from this study should be further validated. |
| spellingShingle | Kamuyu, G Bottomley, C Mageto, J Lowe, B Wilkins, P Noh, J Nutman, T Ngugi, A Odhiambo, R Wagner, R Kakooza-Mwesige, A Owusu-Agyei, S Ae-Ngibise, K Masanja, H Osier, F Odermatt, P Newton, C Exposure to multiple parasites is associated with the prevalence of active convulsive epilepsy in sub-Saharan Africa |
| title | Exposure to multiple parasites is associated with the prevalence of active convulsive epilepsy in sub-Saharan Africa |
| title_full | Exposure to multiple parasites is associated with the prevalence of active convulsive epilepsy in sub-Saharan Africa |
| title_fullStr | Exposure to multiple parasites is associated with the prevalence of active convulsive epilepsy in sub-Saharan Africa |
| title_full_unstemmed | Exposure to multiple parasites is associated with the prevalence of active convulsive epilepsy in sub-Saharan Africa |
| title_short | Exposure to multiple parasites is associated with the prevalence of active convulsive epilepsy in sub-Saharan Africa |
| title_sort | exposure to multiple parasites is associated with the prevalence of active convulsive epilepsy in sub saharan africa |
| work_keys_str_mv | AT kamuyug exposuretomultipleparasitesisassociatedwiththeprevalenceofactiveconvulsiveepilepsyinsubsaharanafrica AT bottomleyc exposuretomultipleparasitesisassociatedwiththeprevalenceofactiveconvulsiveepilepsyinsubsaharanafrica AT magetoj exposuretomultipleparasitesisassociatedwiththeprevalenceofactiveconvulsiveepilepsyinsubsaharanafrica AT loweb exposuretomultipleparasitesisassociatedwiththeprevalenceofactiveconvulsiveepilepsyinsubsaharanafrica AT wilkinsp exposuretomultipleparasitesisassociatedwiththeprevalenceofactiveconvulsiveepilepsyinsubsaharanafrica AT nohj exposuretomultipleparasitesisassociatedwiththeprevalenceofactiveconvulsiveepilepsyinsubsaharanafrica AT nutmant exposuretomultipleparasitesisassociatedwiththeprevalenceofactiveconvulsiveepilepsyinsubsaharanafrica AT ngugia exposuretomultipleparasitesisassociatedwiththeprevalenceofactiveconvulsiveepilepsyinsubsaharanafrica AT odhiambor exposuretomultipleparasitesisassociatedwiththeprevalenceofactiveconvulsiveepilepsyinsubsaharanafrica AT wagnerr exposuretomultipleparasitesisassociatedwiththeprevalenceofactiveconvulsiveepilepsyinsubsaharanafrica AT kakoozamwesigea exposuretomultipleparasitesisassociatedwiththeprevalenceofactiveconvulsiveepilepsyinsubsaharanafrica AT owusuagyeis exposuretomultipleparasitesisassociatedwiththeprevalenceofactiveconvulsiveepilepsyinsubsaharanafrica AT aengibisek exposuretomultipleparasitesisassociatedwiththeprevalenceofactiveconvulsiveepilepsyinsubsaharanafrica AT masanjah exposuretomultipleparasitesisassociatedwiththeprevalenceofactiveconvulsiveepilepsyinsubsaharanafrica AT osierf exposuretomultipleparasitesisassociatedwiththeprevalenceofactiveconvulsiveepilepsyinsubsaharanafrica AT odermattp exposuretomultipleparasitesisassociatedwiththeprevalenceofactiveconvulsiveepilepsyinsubsaharanafrica AT newtonc exposuretomultipleparasitesisassociatedwiththeprevalenceofactiveconvulsiveepilepsyinsubsaharanafrica |