Energy metabolism during chronic endotoxin infusion in the rat, with special reference to free fatty acid turnover.
We have studied various aspects of whole-body energy metabolism during chronic endotoxin infusion in the rat. In particular, we studied free fatty acid kinetics using bolus injections of 14C-palmitate. The general response to 7 days of chronic endotoxin infusion could be divided into an initial 3- t...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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1988
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| _version_ | 1826289139537936384 |
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| author | Goran, M Frayn, K Little, R |
| author_facet | Goran, M Frayn, K Little, R |
| author_sort | Goran, M |
| collection | OXFORD |
| description | We have studied various aspects of whole-body energy metabolism during chronic endotoxin infusion in the rat. In particular, we studied free fatty acid kinetics using bolus injections of 14C-palmitate. The general response to 7 days of chronic endotoxin infusion could be divided into an initial 3- to 4-day period of illness with loss of appetite, followed by rapid recovery. Using saline-infused, pair-fed controls, the following observations were made throughout the 7-day period of endotoxin infusion: 1) Plasma free fatty acids, glycerol and 3-hydroxybutyrate concentrations were reduced; 2) plasma glucose concentrations were elevated; 3) free fatty acid production rates were unaffected; 4) metabolic clearance of free fatty acids was unaffected on day 1 but was significantly greater on days 3 and 7; 5) haematocrits and plasma volumes were elevated. The results suggest that the observed changes in circulating free fatty acid concentrations are more likely to be a consequence of haemodynamic alterations than of metabolic alterations. |
| first_indexed | 2024-03-07T02:24:21Z |
| format | Journal article |
| id | oxford-uuid:a5139b0c-d4f9-4e37-81e0-1bea149ebce4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:24:21Z |
| publishDate | 1988 |
| record_format | dspace |
| spelling | oxford-uuid:a5139b0c-d4f9-4e37-81e0-1bea149ebce42022-03-27T02:37:56ZEnergy metabolism during chronic endotoxin infusion in the rat, with special reference to free fatty acid turnover.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a5139b0c-d4f9-4e37-81e0-1bea149ebce4EnglishSymplectic Elements at Oxford1988Goran, MFrayn, KLittle, RWe have studied various aspects of whole-body energy metabolism during chronic endotoxin infusion in the rat. In particular, we studied free fatty acid kinetics using bolus injections of 14C-palmitate. The general response to 7 days of chronic endotoxin infusion could be divided into an initial 3- to 4-day period of illness with loss of appetite, followed by rapid recovery. Using saline-infused, pair-fed controls, the following observations were made throughout the 7-day period of endotoxin infusion: 1) Plasma free fatty acids, glycerol and 3-hydroxybutyrate concentrations were reduced; 2) plasma glucose concentrations were elevated; 3) free fatty acid production rates were unaffected; 4) metabolic clearance of free fatty acids was unaffected on day 1 but was significantly greater on days 3 and 7; 5) haematocrits and plasma volumes were elevated. The results suggest that the observed changes in circulating free fatty acid concentrations are more likely to be a consequence of haemodynamic alterations than of metabolic alterations. |
| spellingShingle | Goran, M Frayn, K Little, R Energy metabolism during chronic endotoxin infusion in the rat, with special reference to free fatty acid turnover. |
| title | Energy metabolism during chronic endotoxin infusion in the rat, with special reference to free fatty acid turnover. |
| title_full | Energy metabolism during chronic endotoxin infusion in the rat, with special reference to free fatty acid turnover. |
| title_fullStr | Energy metabolism during chronic endotoxin infusion in the rat, with special reference to free fatty acid turnover. |
| title_full_unstemmed | Energy metabolism during chronic endotoxin infusion in the rat, with special reference to free fatty acid turnover. |
| title_short | Energy metabolism during chronic endotoxin infusion in the rat, with special reference to free fatty acid turnover. |
| title_sort | energy metabolism during chronic endotoxin infusion in the rat with special reference to free fatty acid turnover |
| work_keys_str_mv | AT goranm energymetabolismduringchronicendotoxininfusionintheratwithspecialreferencetofreefattyacidturnover AT fraynk energymetabolismduringchronicendotoxininfusionintheratwithspecialreferencetofreefattyacidturnover AT littler energymetabolismduringchronicendotoxininfusionintheratwithspecialreferencetofreefattyacidturnover |