Controlled trial comparing olsalazine and sulphasalazine for the maintenance treatment of ulcerative colitis.
One hundred and sixty four patients with ulcerative colitis in remission were entered into a double blind, double dummy trial comparing olsalazine 500 mg bd and sulphasalazine 1 g bd. Clinical examination, sigmoidoscopy and rectal biopsy were performed at 0, three, and six months. Sixteen of 82 (19....
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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1988
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| _version_ | 1797086616002494464 |
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| author | Ireland, A Mason, C Jewell, D |
| author_facet | Ireland, A Mason, C Jewell, D |
| author_sort | Ireland, A |
| collection | OXFORD |
| description | One hundred and sixty four patients with ulcerative colitis in remission were entered into a double blind, double dummy trial comparing olsalazine 500 mg bd and sulphasalazine 1 g bd. Clinical examination, sigmoidoscopy and rectal biopsy were performed at 0, three, and six months. Sixteen of 82 (19.5%) patients relapsed on olsalazine and 10/82 (12.2%) relapsed on sulphasalazine. The difference was not statistically significant (p = 0.1632). Adverse events were minor and were similar in both groups. No haematological or biochemical abnormalities were detected. Thus, olsalazine is as effective as sulphasalazine for preventing a relapse of ulcerative colitis. |
| first_indexed | 2024-03-07T02:24:26Z |
| format | Journal article |
| id | oxford-uuid:a51b286c-3ef2-42f2-9fda-b05358cda26a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:24:26Z |
| publishDate | 1988 |
| record_format | dspace |
| spelling | oxford-uuid:a51b286c-3ef2-42f2-9fda-b05358cda26a2022-03-27T02:38:08ZControlled trial comparing olsalazine and sulphasalazine for the maintenance treatment of ulcerative colitis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a51b286c-3ef2-42f2-9fda-b05358cda26aEnglishSymplectic Elements at Oxford1988Ireland, AMason, CJewell, DOne hundred and sixty four patients with ulcerative colitis in remission were entered into a double blind, double dummy trial comparing olsalazine 500 mg bd and sulphasalazine 1 g bd. Clinical examination, sigmoidoscopy and rectal biopsy were performed at 0, three, and six months. Sixteen of 82 (19.5%) patients relapsed on olsalazine and 10/82 (12.2%) relapsed on sulphasalazine. The difference was not statistically significant (p = 0.1632). Adverse events were minor and were similar in both groups. No haematological or biochemical abnormalities were detected. Thus, olsalazine is as effective as sulphasalazine for preventing a relapse of ulcerative colitis. |
| spellingShingle | Ireland, A Mason, C Jewell, D Controlled trial comparing olsalazine and sulphasalazine for the maintenance treatment of ulcerative colitis. |
| title | Controlled trial comparing olsalazine and sulphasalazine for the maintenance treatment of ulcerative colitis. |
| title_full | Controlled trial comparing olsalazine and sulphasalazine for the maintenance treatment of ulcerative colitis. |
| title_fullStr | Controlled trial comparing olsalazine and sulphasalazine for the maintenance treatment of ulcerative colitis. |
| title_full_unstemmed | Controlled trial comparing olsalazine and sulphasalazine for the maintenance treatment of ulcerative colitis. |
| title_short | Controlled trial comparing olsalazine and sulphasalazine for the maintenance treatment of ulcerative colitis. |
| title_sort | controlled trial comparing olsalazine and sulphasalazine for the maintenance treatment of ulcerative colitis |
| work_keys_str_mv | AT irelanda controlledtrialcomparingolsalazineandsulphasalazineforthemaintenancetreatmentofulcerativecolitis AT masonc controlledtrialcomparingolsalazineandsulphasalazineforthemaintenancetreatmentofulcerativecolitis AT jewelld controlledtrialcomparingolsalazineandsulphasalazineforthemaintenancetreatmentofulcerativecolitis |