Rationale and design of the coronary artery bypass grafting surgery off or on pump revascularization study: a large international randomized trial in cardiac surgery.
BACKGROUND: Uncertainty remains regarding the benefits and risks of the technique of operating on a beating heart (off pump) for coronary artery bypass grafting (CABG) surgery versus on-pump CABG. Prior trials had few events and relatively short follow-up. There is a need for a large randomized, co...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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2012
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| _version_ | 1797086618794852352 |
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| author | Lamy, A Devereaux, P Prabhakaran, D Hu, S Piegas, L Straka, Z Paolasso, E Taggart, D Lanas, F Akar, A Jain, A Noiseux, N Ou, Y Chrolavicius, S Ng, J Yusuf, S |
| author_facet | Lamy, A Devereaux, P Prabhakaran, D Hu, S Piegas, L Straka, Z Paolasso, E Taggart, D Lanas, F Akar, A Jain, A Noiseux, N Ou, Y Chrolavicius, S Ng, J Yusuf, S |
| author_sort | Lamy, A |
| collection | OXFORD |
| description | BACKGROUND: Uncertainty remains regarding the benefits and risks of the technique of operating on a beating heart (off pump) for coronary artery bypass grafting (CABG) surgery versus on-pump CABG. Prior trials had few events and relatively short follow-up. There is a need for a large randomized, controlled trial with long-term follow-up to inform both the short- and long-term impact of the 2 approaches to CABG. METHODS: We plan to randomize 4,700 patients in whom CABG is planned to undergo the procedure on pump or off pump. The coprimary outcomes are a composite of total mortality, myocardial infarction (MI), stroke, and renal failure at 30 days and a composite of total mortality, MI, stroke, renal failure, and repeat revascularization at 5 years. We will also undertake a cost-effectiveness analysis at 30 days and 5 years after CABG surgery. Other outcomes include neurocognitive dysfunction, recurrence of angina, cardiovascular mortality, blood transfusions, and quality of life. RESULTS: As of May 3, 2011, CORONARY has recruited >3,884 patients from 79 centers in 19 countries. Currently, patient's mean age is 67.6 years, 80.7% are men, 47.0% have a history of diabetes, 51.4% have a history of smoking, and 34.4% had a previous MI. In addition, 20.9% of patients have a left main disease, and 96.6% have double or triple vessel disease. CONCLUSIONS: CORONARY is the largest trial yet conducted comparing off-pump CABG to on-pump CABG. Its results will lead to a better understanding of the safety and efficacy of off-pump CABG. |
| first_indexed | 2024-03-07T02:24:28Z |
| format | Journal article |
| id | oxford-uuid:a51e09ce-790b-4a0b-82a8-a54a885d4cac |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:24:28Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:a51e09ce-790b-4a0b-82a8-a54a885d4cac2022-03-27T02:38:19ZRationale and design of the coronary artery bypass grafting surgery off or on pump revascularization study: a large international randomized trial in cardiac surgery.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a51e09ce-790b-4a0b-82a8-a54a885d4cacEnglishSymplectic Elements at Oxford2012Lamy, ADevereaux, PPrabhakaran, DHu, SPiegas, LStraka, ZPaolasso, ETaggart, DLanas, FAkar, AJain, ANoiseux, NOu, YChrolavicius, SNg, JYusuf, S BACKGROUND: Uncertainty remains regarding the benefits and risks of the technique of operating on a beating heart (off pump) for coronary artery bypass grafting (CABG) surgery versus on-pump CABG. Prior trials had few events and relatively short follow-up. There is a need for a large randomized, controlled trial with long-term follow-up to inform both the short- and long-term impact of the 2 approaches to CABG. METHODS: We plan to randomize 4,700 patients in whom CABG is planned to undergo the procedure on pump or off pump. The coprimary outcomes are a composite of total mortality, myocardial infarction (MI), stroke, and renal failure at 30 days and a composite of total mortality, MI, stroke, renal failure, and repeat revascularization at 5 years. We will also undertake a cost-effectiveness analysis at 30 days and 5 years after CABG surgery. Other outcomes include neurocognitive dysfunction, recurrence of angina, cardiovascular mortality, blood transfusions, and quality of life. RESULTS: As of May 3, 2011, CORONARY has recruited >3,884 patients from 79 centers in 19 countries. Currently, patient's mean age is 67.6 years, 80.7% are men, 47.0% have a history of diabetes, 51.4% have a history of smoking, and 34.4% had a previous MI. In addition, 20.9% of patients have a left main disease, and 96.6% have double or triple vessel disease. CONCLUSIONS: CORONARY is the largest trial yet conducted comparing off-pump CABG to on-pump CABG. Its results will lead to a better understanding of the safety and efficacy of off-pump CABG. |
| spellingShingle | Lamy, A Devereaux, P Prabhakaran, D Hu, S Piegas, L Straka, Z Paolasso, E Taggart, D Lanas, F Akar, A Jain, A Noiseux, N Ou, Y Chrolavicius, S Ng, J Yusuf, S Rationale and design of the coronary artery bypass grafting surgery off or on pump revascularization study: a large international randomized trial in cardiac surgery. |
| title | Rationale and design of the coronary artery bypass grafting surgery off or on pump revascularization study: a large international randomized trial in cardiac surgery. |
| title_full | Rationale and design of the coronary artery bypass grafting surgery off or on pump revascularization study: a large international randomized trial in cardiac surgery. |
| title_fullStr | Rationale and design of the coronary artery bypass grafting surgery off or on pump revascularization study: a large international randomized trial in cardiac surgery. |
| title_full_unstemmed | Rationale and design of the coronary artery bypass grafting surgery off or on pump revascularization study: a large international randomized trial in cardiac surgery. |
| title_short | Rationale and design of the coronary artery bypass grafting surgery off or on pump revascularization study: a large international randomized trial in cardiac surgery. |
| title_sort | rationale and design of the coronary artery bypass grafting surgery off or on pump revascularization study a large international randomized trial in cardiac surgery |
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