Human TLR-7-, -8-, and -9-mediated induction of IFN-alpha/beta and -lambda Is IRAK-4 dependent and redundant for protective immunity to viruses.

Human TLR-7-, -8-, and -9-mediated induction of IFN-alpha/beta and -lambda Is IRAK-4 dependent and redundant for protective immunity to viruses.

Five TLRs are thought to play an important role in antiviral immunity, sensing viral products and inducing IFN-alpha/beta and -lambda. Surprisingly, patients with a defect of IRAK-4, a critical kinase downstream from TLRs, are resistant to common viruses. We show here that IFN-alpha/beta and -lambda...

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Bibliographic Details
Main Authors: Yang, K, Puel, A, Zhang, S, Eidenschenk, C, Ku, C, Casrouge, A, Picard, C, von Bernuth, H, Senechal, B, Plancoulaine, S, Al-Hajjar, S, Al-Ghonaium, A, Maródi, L, Davidson, D, Speert, D, Roifman, C, Garty, B, Ozinsky, A, Barrat, F, Coffman, R, Miller, R, Li, X, Lebon, P, Rodriguez-Gallego, C, Chapel, H
Format: Journal article
Language:English
Published: 2005

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