PRMT inhibition induces a viral mimicry response in triple-negative breast cancer

PRMT inhibition induces a viral mimicry response in triple-negative breast cancer

Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype with the worst prognosis and few effective therapies. Here we identified MS023, an inhibitor of type I protein arginine methyltransferases (PRMTs), which has antitumor growth activity in TNBC. Pathway analysis of TNBC...

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Bibliographic Details
Main Authors: Wu, Q, Nie, DY, Ba-Alawi, W, Ji, Y, Zhang, Z, Cruickshank, J, Haight, J, Ciamponi, FE, Chen, J, Duan, S, Shen, Y, Liu, J, Marhon, SA, Mehdipour, P, Szewczyk, MM, Dogan-Artun, N, Chen, W, Zhang, LX, Deblois, G, Prinos, P, Massirer, KB, Barsyte-Lovejoy, D, Jin, J, De Carvalho, DD, Haibe-Kains, B, Wang, X, Cescon, DW, Lupien, M, Arrowsmith, CH
Format: Journal article
Language:English
Published: Springer Nature 2022
Subjects:
RNA splicing
Chemical genetics
Cancer therapy
Screening

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