Structure-activity relationships of human AKR-type oxidoreductases involved in bile acid synthesis: AKR1D1 and AKR1C4.

Structure-activity relationships of human AKR-type oxidoreductases involved in bile acid synthesis: AKR1D1 and AKR1C4.

Бусад хувилбаруудыг харуулах (1)

Two members of the human aldo-keto reductase (AKR) superfamily participate in the biosynthesis of bile acids by catalyzing the NADP(H) dependent reduction of 3-keto groups (AKR1C4) and Delta4 double bonds (AKR1D1) of oxysterol precursors. Structure determination of human AKR1C4 and homology modellin...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Lee, W, Lukacik, P, Guo, K, Ugochukwu, E, Kavanagh, K, Marsden, B, Oppermann, U
Формат:	Journal article
Хэл сонгох:	English
Хэвлэсэн:	2009
Нөхцлүүд:	biosynthesis Tryptophan Crystallography, X-Ray Structural Homology, Protein Humans Catalytic Domain metabolism Oxidoreductases Ligands Models, Molecular chemistry Structure-Activity Relationship Bile Acids and Salts

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