A comparison of artesunate alone with combined artesunate and quinine in the parenteral treatment of acute falciparum malaria.
In some areas clinicians have combined parenteral artesunate and quinine in the belief that the 2 drugs would be additive or synergistic in severe malaria. A randomized comparison of the effectiveness of intravenous (i.v.) artesunate versus i.v. artesunate and i.v. quinine together on parasite clear...
| Main Authors: | , , , , , , , |
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| Formato: | Journal article |
| Idioma: | English |
| Publicado em: |
2001
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| _version_ | 1826289167770845184 |
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| author | Newton, P Chierakul, W Ruangveerayuth, R Silamut, K Teerapong, P Krudsood, S Looareesuwan, S White, N |
| author_facet | Newton, P Chierakul, W Ruangveerayuth, R Silamut, K Teerapong, P Krudsood, S Looareesuwan, S White, N |
| author_sort | Newton, P |
| collection | OXFORD |
| description | In some areas clinicians have combined parenteral artesunate and quinine in the belief that the 2 drugs would be additive or synergistic in severe malaria. A randomized comparison of the effectiveness of intravenous (i.v.) artesunate versus i.v. artesunate and i.v. quinine together on parasite clearance was conducted in 1998/99 amongst 69 patients with uncomplicated and severe Plasmodium falciparum malaria in western Thailand. The parasite clearance time did not differ significantly between the 2 treatment groups (P = 0.12), but adverse events were significantly more frequent in the artesunate plus quinine group (P = 0.05). Quinine did not have a significant antipyretic effect and artesunate did not affect the electrocardiographic QTc interval. There is no benefit evident from combining parenteral administration of these 2 antimalarial drugs in the acute phase of treatment. |
| first_indexed | 2024-03-07T02:24:46Z |
| format | Journal article |
| id | oxford-uuid:a537f42a-8edf-4a84-8cb1-cadf1d2d4adb |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:24:46Z |
| publishDate | 2001 |
| record_format | dspace |
| spelling | oxford-uuid:a537f42a-8edf-4a84-8cb1-cadf1d2d4adb2022-03-27T02:38:59ZA comparison of artesunate alone with combined artesunate and quinine in the parenteral treatment of acute falciparum malaria.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a537f42a-8edf-4a84-8cb1-cadf1d2d4adbEnglishSymplectic Elements at Oxford2001Newton, PChierakul, WRuangveerayuth, RSilamut, KTeerapong, PKrudsood, SLooareesuwan, SWhite, NIn some areas clinicians have combined parenteral artesunate and quinine in the belief that the 2 drugs would be additive or synergistic in severe malaria. A randomized comparison of the effectiveness of intravenous (i.v.) artesunate versus i.v. artesunate and i.v. quinine together on parasite clearance was conducted in 1998/99 amongst 69 patients with uncomplicated and severe Plasmodium falciparum malaria in western Thailand. The parasite clearance time did not differ significantly between the 2 treatment groups (P = 0.12), but adverse events were significantly more frequent in the artesunate plus quinine group (P = 0.05). Quinine did not have a significant antipyretic effect and artesunate did not affect the electrocardiographic QTc interval. There is no benefit evident from combining parenteral administration of these 2 antimalarial drugs in the acute phase of treatment. |
| spellingShingle | Newton, P Chierakul, W Ruangveerayuth, R Silamut, K Teerapong, P Krudsood, S Looareesuwan, S White, N A comparison of artesunate alone with combined artesunate and quinine in the parenteral treatment of acute falciparum malaria. |
| title | A comparison of artesunate alone with combined artesunate and quinine in the parenteral treatment of acute falciparum malaria. |
| title_full | A comparison of artesunate alone with combined artesunate and quinine in the parenteral treatment of acute falciparum malaria. |
| title_fullStr | A comparison of artesunate alone with combined artesunate and quinine in the parenteral treatment of acute falciparum malaria. |
| title_full_unstemmed | A comparison of artesunate alone with combined artesunate and quinine in the parenteral treatment of acute falciparum malaria. |
| title_short | A comparison of artesunate alone with combined artesunate and quinine in the parenteral treatment of acute falciparum malaria. |
| title_sort | comparison of artesunate alone with combined artesunate and quinine in the parenteral treatment of acute falciparum malaria |
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