DHA mediates the protective effect of fish consumption on new episodes of depression among women
In a longitudinal cohort study of young Australian adults, we reported that for women higher baseline levels of fish consumption were associated with reduced incidence of new depressive episodes during the 5-year follow-up. Fish are high in both n-3 fatty acids and tyrosine. In this study, we seek t...
| Principais autores: | , , , , , , , , |
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| Formato: | Journal article |
| Idioma: | English |
| Publicado em: |
Cambridge University Press
2017
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| _version_ | 1826289169356292096 |
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| author | Reeves, J Otahal, P Magnussen, C Dwyer, T Kangas, A Soininen, P Ala-Korpela, M Venn, A Smith, K |
| author_facet | Reeves, J Otahal, P Magnussen, C Dwyer, T Kangas, A Soininen, P Ala-Korpela, M Venn, A Smith, K |
| author_sort | Reeves, J |
| collection | OXFORD |
| description | In a longitudinal cohort study of young Australian adults, we reported that for women higher baseline levels of fish consumption were associated with reduced incidence of new depressive episodes during the 5-year follow-up. Fish are high in both n-3 fatty acids and tyrosine. In this study, we seek to determine whether n-3 fatty acids or tyrosine explain the observed association. During 2004-2006, a FFQ (nine fish items) was used to estimate weekly fish consumption among 546 women aged 26-36 years. A fasting blood sample was taken and high-throughput NMR spectroscopy was used to measure 233 metabolites, including serum n-3 fatty acids and tyrosine. During 2009-2011, new episodes of depression since baseline were identified using the lifetime version of the Composite International Diagnostic Interview. Relative risks were calculated using log-binomial regression and indirect effects estimated using the STATA binary_mediation command. Potential mediators were added to separate models, and mediation was quantified as the proportion of the total effect due to the mediator. The n-3 DHA mediated 25·3 % of the association between fish consumption and depression when fish consumption was analysed as a continuous variable and 16·6 % when dichotomised (reference group: <2 serves/week). Tyrosine did not mediate the association (<0·1 %). Components in fish other than n-3 fatty acids and tyrosine might be beneficial for women's mental health. |
| first_indexed | 2024-03-07T02:24:48Z |
| format | Journal article |
| id | oxford-uuid:a539f1df-9fd5-46c9-8926-bc6ee7b8fa07 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:24:48Z |
| publishDate | 2017 |
| publisher | Cambridge University Press |
| record_format | dspace |
| spelling | oxford-uuid:a539f1df-9fd5-46c9-8926-bc6ee7b8fa072022-03-27T02:39:03ZDHA mediates the protective effect of fish consumption on new episodes of depression among womenJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a539f1df-9fd5-46c9-8926-bc6ee7b8fa07EnglishSymplectic Elements at OxfordCambridge University Press2017Reeves, JOtahal, PMagnussen, CDwyer, TKangas, ASoininen, PAla-Korpela, MVenn, ASmith, KIn a longitudinal cohort study of young Australian adults, we reported that for women higher baseline levels of fish consumption were associated with reduced incidence of new depressive episodes during the 5-year follow-up. Fish are high in both n-3 fatty acids and tyrosine. In this study, we seek to determine whether n-3 fatty acids or tyrosine explain the observed association. During 2004-2006, a FFQ (nine fish items) was used to estimate weekly fish consumption among 546 women aged 26-36 years. A fasting blood sample was taken and high-throughput NMR spectroscopy was used to measure 233 metabolites, including serum n-3 fatty acids and tyrosine. During 2009-2011, new episodes of depression since baseline were identified using the lifetime version of the Composite International Diagnostic Interview. Relative risks were calculated using log-binomial regression and indirect effects estimated using the STATA binary_mediation command. Potential mediators were added to separate models, and mediation was quantified as the proportion of the total effect due to the mediator. The n-3 DHA mediated 25·3 % of the association between fish consumption and depression when fish consumption was analysed as a continuous variable and 16·6 % when dichotomised (reference group: <2 serves/week). Tyrosine did not mediate the association (<0·1 %). Components in fish other than n-3 fatty acids and tyrosine might be beneficial for women's mental health. |
| spellingShingle | Reeves, J Otahal, P Magnussen, C Dwyer, T Kangas, A Soininen, P Ala-Korpela, M Venn, A Smith, K DHA mediates the protective effect of fish consumption on new episodes of depression among women |
| title | DHA mediates the protective effect of fish consumption on new episodes of depression among women |
| title_full | DHA mediates the protective effect of fish consumption on new episodes of depression among women |
| title_fullStr | DHA mediates the protective effect of fish consumption on new episodes of depression among women |
| title_full_unstemmed | DHA mediates the protective effect of fish consumption on new episodes of depression among women |
| title_short | DHA mediates the protective effect of fish consumption on new episodes of depression among women |
| title_sort | dha mediates the protective effect of fish consumption on new episodes of depression among women |
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