Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS

Increased adiposity is a hallmark of obesity and overweight, which affect 2.2 billion people world-wide. Understanding the genetic and molecular mechanisms that underlie obesity-related phenotypes can help to improve treatment options and drug development. Here we perform promoter Capture Hi-C in hu...

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Príomhchruthaitheoirí: Pan, D, Garske, K, Alvarez, M, Bhagat, Y, Boocock, J, Nikkola, E, Miao, Z, Raulerson, C, Cantor, R, Civelek, M, Glastonbury, C, Small, K, Boehnke, M, Lusis, A, Sinsheimer, J, Mohlke, K, Laakso, M, Pajukanta, P, Ko, A
Formáid: Journal article
Teanga:English
Foilsithe / Cruthaithe: Springer Nature 2018