Does ondansetron attenuate amphetamine-induced behaviour in human volunteers?
The effect of the 5-HT3 receptor antagonist, ondansetron, on the decrease in hunger produced by amphetamine was assessed in nine male volunteers using a double-blind cross-over design. Amphetamine (15 mg orally) produced a significant decrease in self-ratings of hunger 2.5 h after administration. Th...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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1992
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| _version_ | 1826289187613048832 |
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| author | Silverstone, P Johnson, B Cowen, P |
| author_facet | Silverstone, P Johnson, B Cowen, P |
| author_sort | Silverstone, P |
| collection | OXFORD |
| description | The effect of the 5-HT3 receptor antagonist, ondansetron, on the decrease in hunger produced by amphetamine was assessed in nine male volunteers using a double-blind cross-over design. Amphetamine (15 mg orally) produced a significant decrease in self-ratings of hunger 2.5 h after administration. This effect was significantly attenuated by pre-treatment with ondansetron (12 mg orally over 24 h). These findings in humans are consistent with data from animal studies suggesting that ondansetron can attenuate certain catecholamins-mediated behaviours produced by amphetamine. However, explanations founded on pharmacokinetic factors cannot be presently excluded. |
| first_indexed | 2024-03-07T02:25:05Z |
| format | Journal article |
| id | oxford-uuid:a550e5a1-f39d-4f83-b009-4d7ff2186ba1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:25:05Z |
| publishDate | 1992 |
| record_format | dspace |
| spelling | oxford-uuid:a550e5a1-f39d-4f83-b009-4d7ff2186ba12022-03-27T02:39:37ZDoes ondansetron attenuate amphetamine-induced behaviour in human volunteers?Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a550e5a1-f39d-4f83-b009-4d7ff2186ba1EnglishSymplectic Elements at Oxford1992Silverstone, PJohnson, BCowen, PThe effect of the 5-HT3 receptor antagonist, ondansetron, on the decrease in hunger produced by amphetamine was assessed in nine male volunteers using a double-blind cross-over design. Amphetamine (15 mg orally) produced a significant decrease in self-ratings of hunger 2.5 h after administration. This effect was significantly attenuated by pre-treatment with ondansetron (12 mg orally over 24 h). These findings in humans are consistent with data from animal studies suggesting that ondansetron can attenuate certain catecholamins-mediated behaviours produced by amphetamine. However, explanations founded on pharmacokinetic factors cannot be presently excluded. |
| spellingShingle | Silverstone, P Johnson, B Cowen, P Does ondansetron attenuate amphetamine-induced behaviour in human volunteers? |
| title | Does ondansetron attenuate amphetamine-induced behaviour in human volunteers? |
| title_full | Does ondansetron attenuate amphetamine-induced behaviour in human volunteers? |
| title_fullStr | Does ondansetron attenuate amphetamine-induced behaviour in human volunteers? |
| title_full_unstemmed | Does ondansetron attenuate amphetamine-induced behaviour in human volunteers? |
| title_short | Does ondansetron attenuate amphetamine-induced behaviour in human volunteers? |
| title_sort | does ondansetron attenuate amphetamine induced behaviour in human volunteers |
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