Effect of local radiotherapy for bone pain on urinary markers of osteoclast activity.

Urinary markers of bone resorption, pyridinoline and deoxypyridinoline were measured before and at 4 weeks after radiotherapy for metastatic bone pain. An association was shown between relief of metastatic skeletal pain by radiotherapy and low marker concentrations before and after treatment, lendin...

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Bibliographic Details
Main Authors: Hoskin, P, Stratford, MR, Folkes, L, Regan, J, Yarnold, JR
Format: Journal article
Language:English
Published: 2000
Description
Summary:Urinary markers of bone resorption, pyridinoline and deoxypyridinoline were measured before and at 4 weeks after radiotherapy for metastatic bone pain. An association was shown between relief of metastatic skeletal pain by radiotherapy and low marker concentrations before and after treatment, lending support to the hypothesis that relief of metastatic bone pain by radiotherapy relates to an effect on bone, rather than tumour physiology.