Sleep and circadian rhythm disruption in schizophrenia.
BACKGROUND: Sleep disturbances comparable with insomnia occur in up to 80% of people with schizophrenia, but very little is known about the contribution of circadian coordination to these prevalent disruptions. AIMS: A systematic exploration of circadian time patterns in individuals with schizophre...
| मुख्य लेखकों: | , , , , |
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| स्वरूप: | Journal article |
| भाषा: | English |
| प्रकाशित: |
2012
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| _version_ | 1826289201006510080 |
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| author | Wulff, K Dijk, D Middleton, B Foster, R Joyce, E |
| author_facet | Wulff, K Dijk, D Middleton, B Foster, R Joyce, E |
| author_sort | Wulff, K |
| collection | OXFORD |
| description | BACKGROUND: Sleep disturbances comparable with insomnia occur in up to 80% of people with schizophrenia, but very little is known about the contribution of circadian coordination to these prevalent disruptions. AIMS: A systematic exploration of circadian time patterns in individuals with schizophrenia with recurrent sleep disruption. METHOD: We examined the relationship between sleep-wake activity, recorded actigraphically over 6 weeks, along with ambient light exposure and simultaneous circadian clock timing, by collecting weekly 48 h profiles of a urinary metabolite of melatonin in 20 out-patients with schizophrenia and 21 healthy control individuals matched for age, gender and being unemployed. RESULTS: Significant sleep/circadian disruption occurred in all the participants with schizophrenia. Half these individuals showed severe circadian misalignment ranging from phase-advance/delay to non-24 h periods in sleep-wake and melatonin cycles, and the other half showed patterns from excessive sleep to highly irregular and fragmented sleep epochs but with normally timed melatonin production. CONCLUSIONS: Severe circadian sleep/wake disruptions exist despite stability in mood, mental state and newer antipsychotic treatment. They cannot be explained by the individuals' level of everyday function. |
| first_indexed | 2024-03-07T02:25:17Z |
| format | Journal article |
| id | oxford-uuid:a55f8c23-a100-40ef-accb-c4fd41f78127 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:25:17Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:a55f8c23-a100-40ef-accb-c4fd41f781272022-03-27T02:40:03ZSleep and circadian rhythm disruption in schizophrenia.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a55f8c23-a100-40ef-accb-c4fd41f78127EnglishSymplectic Elements at Oxford2012Wulff, KDijk, DMiddleton, BFoster, RJoyce, E BACKGROUND: Sleep disturbances comparable with insomnia occur in up to 80% of people with schizophrenia, but very little is known about the contribution of circadian coordination to these prevalent disruptions. AIMS: A systematic exploration of circadian time patterns in individuals with schizophrenia with recurrent sleep disruption. METHOD: We examined the relationship between sleep-wake activity, recorded actigraphically over 6 weeks, along with ambient light exposure and simultaneous circadian clock timing, by collecting weekly 48 h profiles of a urinary metabolite of melatonin in 20 out-patients with schizophrenia and 21 healthy control individuals matched for age, gender and being unemployed. RESULTS: Significant sleep/circadian disruption occurred in all the participants with schizophrenia. Half these individuals showed severe circadian misalignment ranging from phase-advance/delay to non-24 h periods in sleep-wake and melatonin cycles, and the other half showed patterns from excessive sleep to highly irregular and fragmented sleep epochs but with normally timed melatonin production. CONCLUSIONS: Severe circadian sleep/wake disruptions exist despite stability in mood, mental state and newer antipsychotic treatment. They cannot be explained by the individuals' level of everyday function. |
| spellingShingle | Wulff, K Dijk, D Middleton, B Foster, R Joyce, E Sleep and circadian rhythm disruption in schizophrenia. |
| title | Sleep and circadian rhythm disruption in schizophrenia. |
| title_full | Sleep and circadian rhythm disruption in schizophrenia. |
| title_fullStr | Sleep and circadian rhythm disruption in schizophrenia. |
| title_full_unstemmed | Sleep and circadian rhythm disruption in schizophrenia. |
| title_short | Sleep and circadian rhythm disruption in schizophrenia. |
| title_sort | sleep and circadian rhythm disruption in schizophrenia |
| work_keys_str_mv | AT wulffk sleepandcircadianrhythmdisruptioninschizophrenia AT dijkd sleepandcircadianrhythmdisruptioninschizophrenia AT middletonb sleepandcircadianrhythmdisruptioninschizophrenia AT fosterr sleepandcircadianrhythmdisruptioninschizophrenia AT joycee sleepandcircadianrhythmdisruptioninschizophrenia |