Faster metabolite (1)H transverse relaxation in the elder human brain
(1)H magnetic resonance spectroscopy (MRS) is unique among imaging modalities because signals from several metabolites are measured during a single examination period. Each metabolite reflects a distinct intracellular process. Furthermore transverse (T2 ) relaxation times probe the viability of the...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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Public Library of Science
2013
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| _version_ | 1826289207490904064 |
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| author | Marjańska, M Emir, U Deelchand, D Terpstra, M |
| author_facet | Marjańska, M Emir, U Deelchand, D Terpstra, M |
| author_sort | Marjańska, M |
| collection | OXFORD |
| description | (1)H magnetic resonance spectroscopy (MRS) is unique among imaging modalities because signals from several metabolites are measured during a single examination period. Each metabolite reflects a distinct intracellular process. Furthermore transverse (T2 ) relaxation times probe the viability of the cell microenvironment, e.g., the viscosity of the cellular fluids, the microscopic susceptibility distribution within the cells, and the iron content. In this study, T2s of brain metabolites were measured in the occipital lobe of eighteen young and fourteen elderly subjects at a field strength of 4 tesla. The T2s of N-acetylaspartate, total creatine, and total choline were 23%, 16% and 10% shorter in elderly than in young subjects. The findings of this study suggest that noninvasive detection of T2 provides useful biological information on changes in the cellular microenvironment that take place during aging. |
| first_indexed | 2024-03-07T02:25:22Z |
| format | Journal article |
| id | oxford-uuid:a56669ef-1607-427f-b488-56db6030928c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:25:22Z |
| publishDate | 2013 |
| publisher | Public Library of Science |
| record_format | dspace |
| spelling | oxford-uuid:a56669ef-1607-427f-b488-56db6030928c2022-03-27T02:40:17ZFaster metabolite (1)H transverse relaxation in the elder human brainJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a56669ef-1607-427f-b488-56db6030928cEnglishSymplectic Elements at OxfordPublic Library of Science2013Marjańska, MEmir, UDeelchand, DTerpstra, M(1)H magnetic resonance spectroscopy (MRS) is unique among imaging modalities because signals from several metabolites are measured during a single examination period. Each metabolite reflects a distinct intracellular process. Furthermore transverse (T2 ) relaxation times probe the viability of the cell microenvironment, e.g., the viscosity of the cellular fluids, the microscopic susceptibility distribution within the cells, and the iron content. In this study, T2s of brain metabolites were measured in the occipital lobe of eighteen young and fourteen elderly subjects at a field strength of 4 tesla. The T2s of N-acetylaspartate, total creatine, and total choline were 23%, 16% and 10% shorter in elderly than in young subjects. The findings of this study suggest that noninvasive detection of T2 provides useful biological information on changes in the cellular microenvironment that take place during aging. |
| spellingShingle | Marjańska, M Emir, U Deelchand, D Terpstra, M Faster metabolite (1)H transverse relaxation in the elder human brain |
| title | Faster metabolite (1)H transverse relaxation in the elder human brain |
| title_full | Faster metabolite (1)H transverse relaxation in the elder human brain |
| title_fullStr | Faster metabolite (1)H transverse relaxation in the elder human brain |
| title_full_unstemmed | Faster metabolite (1)H transverse relaxation in the elder human brain |
| title_short | Faster metabolite (1)H transverse relaxation in the elder human brain |
| title_sort | faster metabolite 1 h transverse relaxation in the elder human brain |
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