Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels.

Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels.

We carried out a genome-wide association study of hemoglobin levels in 16,001 individuals of European and Indian Asian ancestry. The most closely associated SNP (rs855791) results in nonsynonymous (V736A) change in the serine protease domain of TMPRSS6 and a blood hemoglobin concentration 0.13 (95%...

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Bibliographic Details
Main Authors: Chambers, J, Zhang, W, Li, Y, Sehmi, J, Wass, M, Zabaneh, D, Hoggart, C, Bayele, H, McCarthy, M, Peltonen, L, Freimer, N, Srai, S, Maxwell, P, Sternberg, M, Ruokonen, A, Abecasis, G, Jarvelin, MR, Scott, J, Elliott, P, Kooner, J
Format: Journal article
Language:English
Published: 2009
Description
Summary:We carried out a genome-wide association study of hemoglobin levels in 16,001 individuals of European and Indian Asian ancestry. The most closely associated SNP (rs855791) results in nonsynonymous (V736A) change in the serine protease domain of TMPRSS6 and a blood hemoglobin concentration 0.13 (95% CI 0.09-0.17) g/dl lower per copy of allele A (P = 1.6 x 10(-13)). Our findings suggest that TMPRSS6, a regulator of hepcidin synthesis and iron handling, is crucial in hemoglobin level maintenance.

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