A fine-scale map of recombination rates and hotspots across the human genome.
Genetic maps, which document the way in which recombination rates vary over a genome, are an essential tool for many genetic analyses. We present a high-resolution genetic map of the human genome, based on statistical analyses of genetic variation data, and identify more than 25,000 recombination ho...
| Автори: | , , , , |
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| Формат: | Journal article |
| Мова: | English |
| Опубліковано: |
2005
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| _version_ | 1826289221238784000 |
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| author | Myers, S Bottolo, L Freeman, C McVean, G Donnelly, P |
| author_facet | Myers, S Bottolo, L Freeman, C McVean, G Donnelly, P |
| author_sort | Myers, S |
| collection | OXFORD |
| description | Genetic maps, which document the way in which recombination rates vary over a genome, are an essential tool for many genetic analyses. We present a high-resolution genetic map of the human genome, based on statistical analyses of genetic variation data, and identify more than 25,000 recombination hotspots, together with motifs and sequence contexts that play a role in hotspot activity. Differences between the behavior of recombination rates over large (megabase) and small (kilobase) scales lead us to suggest a two-stage model for recombination in which hotspots are stochastic features, within a framework in which large-scale rates are constrained. |
| first_indexed | 2024-03-07T02:25:35Z |
| format | Journal article |
| id | oxford-uuid:a575f71a-669a-4346-8d45-64de444259e5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:25:35Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | oxford-uuid:a575f71a-669a-4346-8d45-64de444259e52022-03-27T02:40:45ZA fine-scale map of recombination rates and hotspots across the human genome.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a575f71a-669a-4346-8d45-64de444259e5EnglishSymplectic Elements at Oxford2005Myers, SBottolo, LFreeman, CMcVean, GDonnelly, PGenetic maps, which document the way in which recombination rates vary over a genome, are an essential tool for many genetic analyses. We present a high-resolution genetic map of the human genome, based on statistical analyses of genetic variation data, and identify more than 25,000 recombination hotspots, together with motifs and sequence contexts that play a role in hotspot activity. Differences between the behavior of recombination rates over large (megabase) and small (kilobase) scales lead us to suggest a two-stage model for recombination in which hotspots are stochastic features, within a framework in which large-scale rates are constrained. |
| spellingShingle | Myers, S Bottolo, L Freeman, C McVean, G Donnelly, P A fine-scale map of recombination rates and hotspots across the human genome. |
| title | A fine-scale map of recombination rates and hotspots across the human genome. |
| title_full | A fine-scale map of recombination rates and hotspots across the human genome. |
| title_fullStr | A fine-scale map of recombination rates and hotspots across the human genome. |
| title_full_unstemmed | A fine-scale map of recombination rates and hotspots across the human genome. |
| title_short | A fine-scale map of recombination rates and hotspots across the human genome. |
| title_sort | fine scale map of recombination rates and hotspots across the human genome |
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