Broad-scale recombination patterns underlying proper disjunction in humans.
Although recombination is essential to the successful completion of human meiosis, it remains unclear how tightly the process is regulated and over what scale. To assess the nature and stringency of constraints on human recombination, we examined crossover patterns in transmissions to viable, non-tr...
| Հիմնական հեղինակներ: | , , , , , , |
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| Ձևաչափ: | Journal article |
| Լեզու: | English |
| Հրապարակվել է: |
Public Library of Science
2009
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| _version_ | 1826289245343449088 |
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| author | Fledel-Alon, A Wilson, D Broman, K Wen, X Ober, C Coop, G Przeworski, M |
| author_facet | Fledel-Alon, A Wilson, D Broman, K Wen, X Ober, C Coop, G Przeworski, M |
| author_sort | Fledel-Alon, A |
| collection | OXFORD |
| description | Although recombination is essential to the successful completion of human meiosis, it remains unclear how tightly the process is regulated and over what scale. To assess the nature and stringency of constraints on human recombination, we examined crossover patterns in transmissions to viable, non-trisomic offspring, using dense genotyping data collected in a large set of pedigrees. Our analysis supports a requirement for one chiasma per chromosome rather than per arm to ensure proper disjunction, with additional chiasmata occurring in proportion to physical length. The requirement is not absolute, however, as chromosome 21 seems to be frequently transmitted properly in the absence of a chiasma in females, a finding that raises the possibility of a back-up mechanism aiding in its correct segregation. We also found a set of double crossovers in surprisingly close proximity, as expected from a second pathway that is not subject to crossover interference. These findings point to multiple mechanisms that shape the distribution of crossovers, influencing proper disjunction in humans. |
| first_indexed | 2024-03-07T02:25:57Z |
| format | Journal article |
| id | oxford-uuid:a59b2f61-d461-4260-9ffa-43912841ad65 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:25:57Z |
| publishDate | 2009 |
| publisher | Public Library of Science |
| record_format | dspace |
| spelling | oxford-uuid:a59b2f61-d461-4260-9ffa-43912841ad652022-03-27T02:41:37ZBroad-scale recombination patterns underlying proper disjunction in humans.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a59b2f61-d461-4260-9ffa-43912841ad65EnglishSymplectic Elements at OxfordPublic Library of Science2009Fledel-Alon, AWilson, DBroman, KWen, XOber, CCoop, GPrzeworski, MAlthough recombination is essential to the successful completion of human meiosis, it remains unclear how tightly the process is regulated and over what scale. To assess the nature and stringency of constraints on human recombination, we examined crossover patterns in transmissions to viable, non-trisomic offspring, using dense genotyping data collected in a large set of pedigrees. Our analysis supports a requirement for one chiasma per chromosome rather than per arm to ensure proper disjunction, with additional chiasmata occurring in proportion to physical length. The requirement is not absolute, however, as chromosome 21 seems to be frequently transmitted properly in the absence of a chiasma in females, a finding that raises the possibility of a back-up mechanism aiding in its correct segregation. We also found a set of double crossovers in surprisingly close proximity, as expected from a second pathway that is not subject to crossover interference. These findings point to multiple mechanisms that shape the distribution of crossovers, influencing proper disjunction in humans. |
| spellingShingle | Fledel-Alon, A Wilson, D Broman, K Wen, X Ober, C Coop, G Przeworski, M Broad-scale recombination patterns underlying proper disjunction in humans. |
| title | Broad-scale recombination patterns underlying proper disjunction in humans. |
| title_full | Broad-scale recombination patterns underlying proper disjunction in humans. |
| title_fullStr | Broad-scale recombination patterns underlying proper disjunction in humans. |
| title_full_unstemmed | Broad-scale recombination patterns underlying proper disjunction in humans. |
| title_short | Broad-scale recombination patterns underlying proper disjunction in humans. |
| title_sort | broad scale recombination patterns underlying proper disjunction in humans |
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