Post-streptococcal opsoclonus-myoclonus syndrome associated with anti-neuroleukin antibodies.
BACKGROUND: Adult opsoclonus-myoclonus (OM), a disorder of eye movements accompanied by myoclonus affecting the trunk, limbs, or head, is commonly associated with an underlying malignancy or precipitated by viral infection. METHODS: We present the first two reports of post-streptococcal OM associat...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2006
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| _version_ | 1826289275175436288 |
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| author | Candler, P Dale, R Griffin, S Church, A Wait, R Chapman, MD Keir, G Giovannoni, G Rees, J |
| author_facet | Candler, P Dale, R Griffin, S Church, A Wait, R Chapman, MD Keir, G Giovannoni, G Rees, J |
| author_sort | Candler, P |
| collection | OXFORD |
| description | BACKGROUND: Adult opsoclonus-myoclonus (OM), a disorder of eye movements accompanied by myoclonus affecting the trunk, limbs, or head, is commonly associated with an underlying malignancy or precipitated by viral infection. METHODS: We present the first two reports of post-streptococcal OM associated with antibodies against a 56 kDa protein. Two young girls presented with opsoclonus and myoclonus following a febrile illness and pharyngitis. Protein purification techniques were employed. Amino acid sequences of human neuroleukin (NLK) and streptococcal proteins were compared using the protein-protein BLAST application. RESULTS: The antigen was identified as NLK (glucose-6-phosphate isomerase, GPI). GPI is present on the cell surface of streptococcus making the protein a candidate target for molecular mimicry. CONCLUSIONS: We have identified NLK as an antigenic target in two patients with post-streptococcal OM. The pathogenicity of the antibodies is uncertain. The potential role of anti-neuroleukin antibodies in the pathogenesis of OM is discussed. We propose that OM may represent a further syndrome in the growing spectrum of post-streptococcal neurological disorders. The role of streptococcus in OM and the frequency with which anti-NLK responses occur in both post-infectious and paraneoplastic OM should be investigated further. |
| first_indexed | 2024-03-07T02:26:24Z |
| format | Journal article |
| id | oxford-uuid:a5c25d7c-7fb0-473a-a830-98c215e40999 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:26:24Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:a5c25d7c-7fb0-473a-a830-98c215e409992022-03-27T02:42:35ZPost-streptococcal opsoclonus-myoclonus syndrome associated with anti-neuroleukin antibodies.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a5c25d7c-7fb0-473a-a830-98c215e40999EnglishSymplectic Elements at Oxford2006Candler, PDale, RGriffin, SChurch, AWait, RChapman, MDKeir, GGiovannoni, GRees, J BACKGROUND: Adult opsoclonus-myoclonus (OM), a disorder of eye movements accompanied by myoclonus affecting the trunk, limbs, or head, is commonly associated with an underlying malignancy or precipitated by viral infection. METHODS: We present the first two reports of post-streptococcal OM associated with antibodies against a 56 kDa protein. Two young girls presented with opsoclonus and myoclonus following a febrile illness and pharyngitis. Protein purification techniques were employed. Amino acid sequences of human neuroleukin (NLK) and streptococcal proteins were compared using the protein-protein BLAST application. RESULTS: The antigen was identified as NLK (glucose-6-phosphate isomerase, GPI). GPI is present on the cell surface of streptococcus making the protein a candidate target for molecular mimicry. CONCLUSIONS: We have identified NLK as an antigenic target in two patients with post-streptococcal OM. The pathogenicity of the antibodies is uncertain. The potential role of anti-neuroleukin antibodies in the pathogenesis of OM is discussed. We propose that OM may represent a further syndrome in the growing spectrum of post-streptococcal neurological disorders. The role of streptococcus in OM and the frequency with which anti-NLK responses occur in both post-infectious and paraneoplastic OM should be investigated further. |
| spellingShingle | Candler, P Dale, R Griffin, S Church, A Wait, R Chapman, MD Keir, G Giovannoni, G Rees, J Post-streptococcal opsoclonus-myoclonus syndrome associated with anti-neuroleukin antibodies. |
| title | Post-streptococcal opsoclonus-myoclonus syndrome associated with anti-neuroleukin antibodies. |
| title_full | Post-streptococcal opsoclonus-myoclonus syndrome associated with anti-neuroleukin antibodies. |
| title_fullStr | Post-streptococcal opsoclonus-myoclonus syndrome associated with anti-neuroleukin antibodies. |
| title_full_unstemmed | Post-streptococcal opsoclonus-myoclonus syndrome associated with anti-neuroleukin antibodies. |
| title_short | Post-streptococcal opsoclonus-myoclonus syndrome associated with anti-neuroleukin antibodies. |
| title_sort | post streptococcal opsoclonus myoclonus syndrome associated with anti neuroleukin antibodies |
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