Antimalarial drug susceptibility of Plasmodium vivax in the Republic of Korea.
The antimalarial susceptibility of ring stage (> 80%) Plasmodium vivax from the Republic of Korea, where long incubation-period strains are prevalent, was evaluated using the schizont maturation inhibition technique. During 2005-2007, susceptibility to seven antimalarial drugs was evaluated w...
| Những tác giả chính: | , , , , , , , , |
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| Định dạng: | Journal article |
| Ngôn ngữ: | English |
| Được phát hành: |
2009
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| _version_ | 1826289283942580224 |
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| author | Chotivanich, K Sattabongkot, J Choi, Y Park, J Sritabal, J Lim, C Udomsangpetch, R White, N Lee, W |
| author_facet | Chotivanich, K Sattabongkot, J Choi, Y Park, J Sritabal, J Lim, C Udomsangpetch, R White, N Lee, W |
| author_sort | Chotivanich, K |
| collection | OXFORD |
| description | The antimalarial susceptibility of ring stage (> 80%) Plasmodium vivax from the Republic of Korea, where long incubation-period strains are prevalent, was evaluated using the schizont maturation inhibition technique. During 2005-2007, susceptibility to seven antimalarial drugs was evaluated with 24 fresh isolates. The geometric mean (95% confidence interval) 50% inhibition concentration (IC(50)) were quinine 60 (54-75) ng/mL, chloroquine 39 (22-282) ng/mL, piperaquine 27 (17-58) ng/mL, mefloquine 39 (35-67) ng/mL, pyrimethamine 138 (89-280) ng/mL, artesunate 0.6 (0.5-0.8) ng/mL, and primaquine 122 (98-232) ng/mL. Positive correlations were found between quinine and mefloquine (r = 0.6, P = 0.004), piperaquine and chloroquine (r = 0.6, P = 0.008), and piperaquine and primaquine IC(50) values (r = 0.5, P = 0.01). Compared with P. vivax in Thailand, P. vivax in the Republic of Korea was more sensitive to quinine and mefloquine, but equally sensitive to chloroquine and artesunate. |
| first_indexed | 2024-03-07T02:26:32Z |
| format | Journal article |
| id | oxford-uuid:a5cb928e-df72-4433-bcef-fb99efcb6ea2 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:26:32Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:a5cb928e-df72-4433-bcef-fb99efcb6ea22022-03-27T02:42:57ZAntimalarial drug susceptibility of Plasmodium vivax in the Republic of Korea.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a5cb928e-df72-4433-bcef-fb99efcb6ea2EnglishSymplectic Elements at Oxford2009Chotivanich, KSattabongkot, JChoi, YPark, JSritabal, JLim, CUdomsangpetch, RWhite, NLee, WThe antimalarial susceptibility of ring stage (> 80%) Plasmodium vivax from the Republic of Korea, where long incubation-period strains are prevalent, was evaluated using the schizont maturation inhibition technique. During 2005-2007, susceptibility to seven antimalarial drugs was evaluated with 24 fresh isolates. The geometric mean (95% confidence interval) 50% inhibition concentration (IC(50)) were quinine 60 (54-75) ng/mL, chloroquine 39 (22-282) ng/mL, piperaquine 27 (17-58) ng/mL, mefloquine 39 (35-67) ng/mL, pyrimethamine 138 (89-280) ng/mL, artesunate 0.6 (0.5-0.8) ng/mL, and primaquine 122 (98-232) ng/mL. Positive correlations were found between quinine and mefloquine (r = 0.6, P = 0.004), piperaquine and chloroquine (r = 0.6, P = 0.008), and piperaquine and primaquine IC(50) values (r = 0.5, P = 0.01). Compared with P. vivax in Thailand, P. vivax in the Republic of Korea was more sensitive to quinine and mefloquine, but equally sensitive to chloroquine and artesunate. |
| spellingShingle | Chotivanich, K Sattabongkot, J Choi, Y Park, J Sritabal, J Lim, C Udomsangpetch, R White, N Lee, W Antimalarial drug susceptibility of Plasmodium vivax in the Republic of Korea. |
| title | Antimalarial drug susceptibility of Plasmodium vivax in the Republic of Korea. |
| title_full | Antimalarial drug susceptibility of Plasmodium vivax in the Republic of Korea. |
| title_fullStr | Antimalarial drug susceptibility of Plasmodium vivax in the Republic of Korea. |
| title_full_unstemmed | Antimalarial drug susceptibility of Plasmodium vivax in the Republic of Korea. |
| title_short | Antimalarial drug susceptibility of Plasmodium vivax in the Republic of Korea. |
| title_sort | antimalarial drug susceptibility of plasmodium vivax in the republic of korea |
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