Synthesis of [4S‐2H]NADH, [4R‐2H]NADH, [4‐2H2]NADH and [4‐2H]NAD+ cofactors through heterogeneous biocatalysis in heavy water
This practitioner protocol describes the synthesis of a family of deuterated nicotinamide cofactors: [4S‐2H]NADH, [4R‐2H]NADH, [4‐2H2]NADH and [4‐2H]NAD+. The application of a recently developed H2‐driven heterogeneous biocatalyst enables the cofactors to be prepared with high (>90%) 2H‐incorpora...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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Wiley
2021
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| _version_ | 1826289294082310144 |
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| author | Rowbotham, JS Hardy, AP Reeve, HA Vincent, KA |
| author_facet | Rowbotham, JS Hardy, AP Reeve, HA Vincent, KA |
| author_sort | Rowbotham, JS |
| collection | OXFORD |
| description | This practitioner protocol describes the synthesis of a family of deuterated nicotinamide cofactors: [4S‐2H]NADH, [4R‐2H]NADH, [4‐2H2]NADH and [4‐2H]NAD+. The application of a recently developed H2‐driven heterogeneous biocatalyst enables the cofactors to be prepared with high (>90%) 2H‐incorporation with 2H2O as the only isotope source. |
| first_indexed | 2024-03-07T02:26:42Z |
| format | Journal article |
| id | oxford-uuid:a5d9fbfe-2042-4430-823c-cf80f3944f1f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:26:42Z |
| publishDate | 2021 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:a5d9fbfe-2042-4430-823c-cf80f3944f1f2022-03-27T02:43:16ZSynthesis of [4S‐2H]NADH, [4R‐2H]NADH, [4‐2H2]NADH and [4‐2H]NAD+ cofactors through heterogeneous biocatalysis in heavy waterJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a5d9fbfe-2042-4430-823c-cf80f3944f1fEnglishSymplectic ElementsWiley2021Rowbotham, JSHardy, APReeve, HAVincent, KAThis practitioner protocol describes the synthesis of a family of deuterated nicotinamide cofactors: [4S‐2H]NADH, [4R‐2H]NADH, [4‐2H2]NADH and [4‐2H]NAD+. The application of a recently developed H2‐driven heterogeneous biocatalyst enables the cofactors to be prepared with high (>90%) 2H‐incorporation with 2H2O as the only isotope source. |
| spellingShingle | Rowbotham, JS Hardy, AP Reeve, HA Vincent, KA Synthesis of [4S‐2H]NADH, [4R‐2H]NADH, [4‐2H2]NADH and [4‐2H]NAD+ cofactors through heterogeneous biocatalysis in heavy water |
| title | Synthesis of [4S‐2H]NADH, [4R‐2H]NADH, [4‐2H2]NADH and [4‐2H]NAD+ cofactors through heterogeneous biocatalysis in heavy water |
| title_full | Synthesis of [4S‐2H]NADH, [4R‐2H]NADH, [4‐2H2]NADH and [4‐2H]NAD+ cofactors through heterogeneous biocatalysis in heavy water |
| title_fullStr | Synthesis of [4S‐2H]NADH, [4R‐2H]NADH, [4‐2H2]NADH and [4‐2H]NAD+ cofactors through heterogeneous biocatalysis in heavy water |
| title_full_unstemmed | Synthesis of [4S‐2H]NADH, [4R‐2H]NADH, [4‐2H2]NADH and [4‐2H]NAD+ cofactors through heterogeneous biocatalysis in heavy water |
| title_short | Synthesis of [4S‐2H]NADH, [4R‐2H]NADH, [4‐2H2]NADH and [4‐2H]NAD+ cofactors through heterogeneous biocatalysis in heavy water |
| title_sort | synthesis of 4s 2h nadh 4r 2h nadh 4 2h2 nadh and 4 2h nad cofactors through heterogeneous biocatalysis in heavy water |
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