Development of immunotherapy combination strategies in cancer
Harnessing the immune system to treat cancer through inhibitors of CTLA4 and PD-L1 has revolutionized the landscape of cancer. Rational combination strategies aim to enhance the antitumor effects of immunotherapies, but require a deep understanding of the mechanistic underpinnings of the immune syst...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
American Association for Cancer Research
2021
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| _version_ | 1826308588266586112 |
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| author | Parkes, EE Yap, TA Peng, W Moyers, JT Curran, MA Tawbi, HA |
| author_facet | Parkes, EE Yap, TA Peng, W Moyers, JT Curran, MA Tawbi, HA |
| author_sort | Parkes, EE |
| collection | OXFORD |
| description | Harnessing the immune system to treat cancer through inhibitors of CTLA4 and PD-L1 has revolutionized the landscape of cancer. Rational combination strategies aim to enhance the antitumor effects of immunotherapies, but require a deep understanding of the mechanistic underpinnings of the immune system and robust preclinical and clinical drug development strategies. We review the current approved immunotherapy combinations, before discussing promising combinatorial approaches in clinical trials and detailing innovative preclinical model systems being used to develop rational combinations. We also discuss the promise of high-order immunotherapy combinations, as well as novel biomarker and combinatorial trial strategies. SIGNIFICANCE: Although immune-checkpoint inhibitors are approved as dual checkpoint strategies, and in combination with cytotoxic chemotherapy and angiogenesis inhibitors for multiple cancers, patient benefit remains limited. Innovative approaches are required to guide the development of novel immunotherapy combinations, ranging from improvements in preclinical tumor model systems to biomarker-driven trial strategies. |
| first_indexed | 2024-03-07T07:21:37Z |
| format | Journal article |
| id | oxford-uuid:a5db9509-145e-4683-b067-0b77de13627a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:21:37Z |
| publishDate | 2021 |
| publisher | American Association for Cancer Research |
| record_format | dspace |
| spelling | oxford-uuid:a5db9509-145e-4683-b067-0b77de13627a2022-10-20T11:08:57ZDevelopment of immunotherapy combination strategies in cancerJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a5db9509-145e-4683-b067-0b77de13627aEnglishSymplectic ElementsAmerican Association for Cancer Research2021Parkes, EEYap, TAPeng, WMoyers, JTCurran, MATawbi, HAHarnessing the immune system to treat cancer through inhibitors of CTLA4 and PD-L1 has revolutionized the landscape of cancer. Rational combination strategies aim to enhance the antitumor effects of immunotherapies, but require a deep understanding of the mechanistic underpinnings of the immune system and robust preclinical and clinical drug development strategies. We review the current approved immunotherapy combinations, before discussing promising combinatorial approaches in clinical trials and detailing innovative preclinical model systems being used to develop rational combinations. We also discuss the promise of high-order immunotherapy combinations, as well as novel biomarker and combinatorial trial strategies. SIGNIFICANCE: Although immune-checkpoint inhibitors are approved as dual checkpoint strategies, and in combination with cytotoxic chemotherapy and angiogenesis inhibitors for multiple cancers, patient benefit remains limited. Innovative approaches are required to guide the development of novel immunotherapy combinations, ranging from improvements in preclinical tumor model systems to biomarker-driven trial strategies. |
| spellingShingle | Parkes, EE Yap, TA Peng, W Moyers, JT Curran, MA Tawbi, HA Development of immunotherapy combination strategies in cancer |
| title | Development of immunotherapy combination strategies in cancer |
| title_full | Development of immunotherapy combination strategies in cancer |
| title_fullStr | Development of immunotherapy combination strategies in cancer |
| title_full_unstemmed | Development of immunotherapy combination strategies in cancer |
| title_short | Development of immunotherapy combination strategies in cancer |
| title_sort | development of immunotherapy combination strategies in cancer |
| work_keys_str_mv | AT parkesee developmentofimmunotherapycombinationstrategiesincancer AT yapta developmentofimmunotherapycombinationstrategiesincancer AT pengw developmentofimmunotherapycombinationstrategiesincancer AT moyersjt developmentofimmunotherapycombinationstrategiesincancer AT curranma developmentofimmunotherapycombinationstrategiesincancer AT tawbiha developmentofimmunotherapycombinationstrategiesincancer |