Structure of the human cation-independent mannose 6-phosphate/IGF2 receptor domains 7–11 uncovers the mannose 6-phosphate binding site of domain 9

Structure of the human cation-independent mannose 6-phosphate/IGF2 receptor domains 7–11 uncovers the mannose 6-phosphate binding site of domain 9

The cation-independent mannose 6-phosphate (M6P)/Insulin-like growth factor-2 receptor (CI-MPR/IGF2R) is an ∼300 kDa transmembrane protein responsible for trafficking M6P-tagged lysosomal hydrolases and internalizing IGF2. The extracellular region of the CI-MPR has 15 homologous domains, including M...

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Bibliographic Details
Main Authors:	Bochel, AJ, Williams, C, McCoy, AJ, Hoppe, H-J, Winter, AJ, Nicholls, RD, Harlos, K, Jones, EY, Berger, I, Hassan, AB, Crump, MP
Format:	Journal article
Language:	English
Published:	Cell Press 2020

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