Structure of the human cation-independent mannose 6-phosphate/IGF2 receptor domains 7–11 uncovers the mannose 6-phosphate binding site of domain 9

The cation-independent mannose 6-phosphate (M6P)/Insulin-like growth factor-2 receptor (CI-MPR/IGF2R) is an ∼300 kDa transmembrane protein responsible for trafficking M6P-tagged lysosomal hydrolases and internalizing IGF2. The extracellular region of the CI-MPR has 15 homologous domains, including M...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों: Bochel, AJ, Williams, C, McCoy, AJ, Hoppe, H-J, Winter, AJ, Nicholls, RD, Harlos, K, Jones, EY, Berger, I, Hassan, AB, Crump, MP
स्वरूप: Journal article
भाषा:English
प्रकाशित: Cell Press 2020