New perspectives on the ligands and function of the killer cell immunoglobulin-like receptor KIR3DL2 in health and disease.

KIR3DL2/CD158k/p140 is a three domain killer cell immunoglobulin-like receptor incorporating cytoplasmic immunoreceptor tyrosine inhibitory motifs, expressed as a disulphide-bonded dimer. KIR3DL2 is a framework gene within the KIR locus and is highly polymorphic, with 62 allelic variants possibly co...

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Main Authors: Shaw, J, Kollnberger, S
Format: Journal article
Language:English
Published: 2012
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author Shaw, J
Kollnberger, S
author_facet Shaw, J
Kollnberger, S
author_sort Shaw, J
collection OXFORD
description KIR3DL2/CD158k/p140 is a three domain killer cell immunoglobulin-like receptor incorporating cytoplasmic immunoreceptor tyrosine inhibitory motifs, expressed as a disulphide-bonded dimer. KIR3DL2 is a framework gene within the KIR locus and is highly polymorphic, with 62 allelic variants possibly coding for protein reported. KIR3DL2 binds to HLA-A3 and -A11 in a peptide-dependent fashion and to B27 free heavy chain forms. In addition, KIR3DL2 can also function as an innate immune receptor for delivery of CpG DNA to TLR9 in NK cells. The increased levels of expression of KIR3DL2 compared with other KIR expressed by T cell subsets in healthy individuals suggest it may function as a default KIR receptor. KIR3DL2-expressing natural killer (NK) cells and IL17 secreting CD4 T cells have been implicated in the pathogenesis of ankylosing spondylitis. Moreover, KIR3DL2 expression delineates circulating and cutaneous lymphoma T cells in Sézary's syndrome. Here we discuss how the unique molecular attributes of KIR3DL2 impact on its function on NK and T cells and how this may relate to its role in disease.
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spelling oxford-uuid:a60ccf0b-3af1-4a5f-b604-3a8a92f25b462022-03-27T02:44:31ZNew perspectives on the ligands and function of the killer cell immunoglobulin-like receptor KIR3DL2 in health and disease.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a60ccf0b-3af1-4a5f-b604-3a8a92f25b46EnglishSymplectic Elements at Oxford2012Shaw, JKollnberger, SKIR3DL2/CD158k/p140 is a three domain killer cell immunoglobulin-like receptor incorporating cytoplasmic immunoreceptor tyrosine inhibitory motifs, expressed as a disulphide-bonded dimer. KIR3DL2 is a framework gene within the KIR locus and is highly polymorphic, with 62 allelic variants possibly coding for protein reported. KIR3DL2 binds to HLA-A3 and -A11 in a peptide-dependent fashion and to B27 free heavy chain forms. In addition, KIR3DL2 can also function as an innate immune receptor for delivery of CpG DNA to TLR9 in NK cells. The increased levels of expression of KIR3DL2 compared with other KIR expressed by T cell subsets in healthy individuals suggest it may function as a default KIR receptor. KIR3DL2-expressing natural killer (NK) cells and IL17 secreting CD4 T cells have been implicated in the pathogenesis of ankylosing spondylitis. Moreover, KIR3DL2 expression delineates circulating and cutaneous lymphoma T cells in Sézary's syndrome. Here we discuss how the unique molecular attributes of KIR3DL2 impact on its function on NK and T cells and how this may relate to its role in disease.
spellingShingle Shaw, J
Kollnberger, S
New perspectives on the ligands and function of the killer cell immunoglobulin-like receptor KIR3DL2 in health and disease.
title New perspectives on the ligands and function of the killer cell immunoglobulin-like receptor KIR3DL2 in health and disease.
title_full New perspectives on the ligands and function of the killer cell immunoglobulin-like receptor KIR3DL2 in health and disease.
title_fullStr New perspectives on the ligands and function of the killer cell immunoglobulin-like receptor KIR3DL2 in health and disease.
title_full_unstemmed New perspectives on the ligands and function of the killer cell immunoglobulin-like receptor KIR3DL2 in health and disease.
title_short New perspectives on the ligands and function of the killer cell immunoglobulin-like receptor KIR3DL2 in health and disease.
title_sort new perspectives on the ligands and function of the killer cell immunoglobulin like receptor kir3dl2 in health and disease
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