Multi-ethnic genome-wide association study for atrial fibrillation
Atrial fibrillation (AF) affects more than 33 million individuals worldwide1 and has a complex heritability2. We conducted the largest meta-analysis of genome-wide association studies (GWAS) for AF to date, consisting of more than half a million individuals, including 65,446 with AF. In total, we id...
| Những tác giả chính: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Định dạng: | Journal article |
| Ngôn ngữ: | English |
| Được phát hành: |
Nature Publishing Group
2018
|
| _version_ | 1826289344745308160 |
|---|---|
| author | Roselli, C Chaffin, MD Weng, L-C Aeschbacher, S Ahlberg, G Albert, CM Almgren, P Alonso, A Anderson, CD Aragam, KG Arking, DE Barnard, J Bartz, TM Benjamin, EJ Bihlmeyer, NA Bis, JC Bloom, HL Boerwinkle, E Bottinger, EB Brody, JA Calkins, H Campbell, A Cappola, TP Carlquist, J Chasman, DI Chen, LY Chen, Y-DI Choi, E-K Choi, SH Christophersen, IE Chung, MK Cole, JW Conen, D Cook, J Crijns, HJ Cutler, MJ Damrauer, SM Daniels, BR Darbar, D Delgado, G Denny, JC Dichgans, M Dörr, M Dudink, EA Dudley, SC Esa, N Esko, T Eskola, M Fatkin, D Felix, SB Ford, I Franco, OH Geelhoed, B Grewal, RP Gudnason, V Guo, X Gupta, N Gustafsson, S Gutmann, R Hamsten, A Harris, TB Hayward, C Heckbert, SR Hernesniemi, J Hocking, LJ Hofman, A Horimoto, ARVR Huang, J Huang, PL Huffman, J Ingelsson, E Ipek, EG Ito, K Jimenez-Conde, J Johnson, R Jukema, JW Kääb, S Kähönen, M Kamatani, Y Kane, JP Kastrati, A Kathiresan, S Katschnig-Winter, P Kavousi, M Kessler, T Kietselaer, BL Kirchhof, P Kleber, ME Knight, S Krieger, JE Kubo, M Launer, LJ Laurikka, J Lehtimäki, T Leineweber, K Lemaitre, RN Li, M Lim, HE Lin, HJ Lin, H Lind, L Lindgren, CM Lokki, M-L London, B Loos, RJF Low, S-K Lu, Y Lyytikäinen, L-P Macfarlane, PW Magnusson, PK Mahajan, A Malik, R Mansur, AJ Marcus, GM Margolin, L Margulies, KB März, W McManus, DD Melander, O Mohanty, S Montgomery, JA Morley, MP Morris, AP Müller-Nurasyid, M Natale, A Nazarian, S Neumann, B Newton-Cheh, C Niemeijer, MN Nikus, K Nilsson, P Noordam, R Oellers, H Olesen, MS Orho-Melander, M Padmanabhan, S Pak, H-N Paré, G Pedersen, NL Pera, J Pereira, A Porteous, D Psaty, BM Pulit, SL Pullinger, CR Rader, DJ Refsgaard, L Ribasés, M Ridker, PM Rienstra, M Risch, L Roden, DM Rosand, J Rosenberg, MA Rost, N Rotter, JI Saba, S Sandhu, RK Schnabel, RB Schramm, K Schunkert, H Schurman, C Scott, SA Seppälä, I Shaffer, C Shah, S Shalaby, AA Shim, J Shoemaker, MB Siland, JE Sinisalo, J Sinner, MF Slowik, A Smith, AV Smith, BH Smith, JG Smith, JD Smith, NL Soliman, EZ Sotoodehnia, N Stricker, BH Sun, A Sun, H Svendsen, JH Tanaka, T Tanriverdi, K Taylor, KD Teder-Laving, M Teumer, A Thériault, S Trompet, S Tucker, NR Tveit, A Uitterlinden, AG Van Der Harst, P Van Gelder, IC Van Wagoner, DR Verweij, N Vlachopoulou, E Völker, U Wang, B Weeke, PE Weijs, B Weiss, R Weiss, S Wells, QS Wiggins, KL Wong, JA Woo, D Worrall, BB Yang, P-S Yao, J Yoneda, ZT Zeller, T Zeng, L Lubitz, SA Lunetta, KL Ellinor, PT |
| author_facet | Roselli, C Chaffin, MD Weng, L-C Aeschbacher, S Ahlberg, G Albert, CM Almgren, P Alonso, A Anderson, CD Aragam, KG Arking, DE Barnard, J Bartz, TM Benjamin, EJ Bihlmeyer, NA Bis, JC Bloom, HL Boerwinkle, E Bottinger, EB Brody, JA Calkins, H Campbell, A Cappola, TP Carlquist, J Chasman, DI Chen, LY Chen, Y-DI Choi, E-K Choi, SH Christophersen, IE Chung, MK Cole, JW Conen, D Cook, J Crijns, HJ Cutler, MJ Damrauer, SM Daniels, BR Darbar, D Delgado, G Denny, JC Dichgans, M Dörr, M Dudink, EA Dudley, SC Esa, N Esko, T Eskola, M Fatkin, D Felix, SB Ford, I Franco, OH Geelhoed, B Grewal, RP Gudnason, V Guo, X Gupta, N Gustafsson, S Gutmann, R Hamsten, A Harris, TB Hayward, C Heckbert, SR Hernesniemi, J Hocking, LJ Hofman, A Horimoto, ARVR Huang, J Huang, PL Huffman, J Ingelsson, E Ipek, EG Ito, K Jimenez-Conde, J Johnson, R Jukema, JW Kääb, S Kähönen, M Kamatani, Y Kane, JP Kastrati, A Kathiresan, S Katschnig-Winter, P Kavousi, M Kessler, T Kietselaer, BL Kirchhof, P Kleber, ME Knight, S Krieger, JE Kubo, M Launer, LJ Laurikka, J Lehtimäki, T Leineweber, K Lemaitre, RN Li, M Lim, HE Lin, HJ Lin, H Lind, L Lindgren, CM Lokki, M-L London, B Loos, RJF Low, S-K Lu, Y Lyytikäinen, L-P Macfarlane, PW Magnusson, PK Mahajan, A Malik, R Mansur, AJ Marcus, GM Margolin, L Margulies, KB März, W McManus, DD Melander, O Mohanty, S Montgomery, JA Morley, MP Morris, AP Müller-Nurasyid, M Natale, A Nazarian, S Neumann, B Newton-Cheh, C Niemeijer, MN Nikus, K Nilsson, P Noordam, R Oellers, H Olesen, MS Orho-Melander, M Padmanabhan, S Pak, H-N Paré, G Pedersen, NL Pera, J Pereira, A Porteous, D Psaty, BM Pulit, SL Pullinger, CR Rader, DJ Refsgaard, L Ribasés, M Ridker, PM Rienstra, M Risch, L Roden, DM Rosand, J Rosenberg, MA Rost, N Rotter, JI Saba, S Sandhu, RK Schnabel, RB Schramm, K Schunkert, H Schurman, C Scott, SA Seppälä, I Shaffer, C Shah, S Shalaby, AA Shim, J Shoemaker, MB Siland, JE Sinisalo, J Sinner, MF Slowik, A Smith, AV Smith, BH Smith, JG Smith, JD Smith, NL Soliman, EZ Sotoodehnia, N Stricker, BH Sun, A Sun, H Svendsen, JH Tanaka, T Tanriverdi, K Taylor, KD Teder-Laving, M Teumer, A Thériault, S Trompet, S Tucker, NR Tveit, A Uitterlinden, AG Van Der Harst, P Van Gelder, IC Van Wagoner, DR Verweij, N Vlachopoulou, E Völker, U Wang, B Weeke, PE Weijs, B Weiss, R Weiss, S Wells, QS Wiggins, KL Wong, JA Woo, D Worrall, BB Yang, P-S Yao, J Yoneda, ZT Zeller, T Zeng, L Lubitz, SA Lunetta, KL Ellinor, PT |
| author_sort | Roselli, C |
| collection | OXFORD |
| description | Atrial fibrillation (AF) affects more than 33 million individuals worldwide1 and has a complex heritability2. We conducted the largest meta-analysis of genome-wide association studies (GWAS) for AF to date, consisting of more than half a million individuals, including 65,446 with AF. In total, we identified 97 loci significantly associated with AF, including 67 that were novel in a combined-ancestry analysis, and 3 that were novel in a European-specific analysis. We sought to identify AF-associated genes at the GWAS loci by performing RNA-sequencing and expression quantitative trait locus analyses in 101 left atrial samples, the most relevant tissue for AF. We also performed transcriptome-wide analyses that identified 57 AF-associated genes, 42 of which overlap with GWAS loci. The identified loci implicate genes enriched within cardiac developmental, electrophysiological, contractile and structural pathways. These results extend our understanding of the biological pathways underlying AF and may facilitate the development of therapeutics for AF. |
| first_indexed | 2024-03-07T02:27:27Z |
| format | Journal article |
| id | oxford-uuid:a618de2a-06d0-4000-b77c-024e93fa4074 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:27:27Z |
| publishDate | 2018 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:a618de2a-06d0-4000-b77c-024e93fa40742022-03-27T02:45:30ZMulti-ethnic genome-wide association study for atrial fibrillationJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a618de2a-06d0-4000-b77c-024e93fa4074EnglishSymplectic Elements at OxfordNature Publishing Group2018Roselli, CChaffin, MDWeng, L-CAeschbacher, SAhlberg, GAlbert, CMAlmgren, PAlonso, AAnderson, CDAragam, KGArking, DEBarnard, JBartz, TMBenjamin, EJBihlmeyer, NABis, JCBloom, HLBoerwinkle, EBottinger, EBBrody, JACalkins, HCampbell, ACappola, TPCarlquist, JChasman, DIChen, LYChen, Y-DIChoi, E-KChoi, SHChristophersen, IEChung, MKCole, JWConen, DCook, JCrijns, HJCutler, MJDamrauer, SMDaniels, BRDarbar, DDelgado, GDenny, JCDichgans, MDörr, MDudink, EADudley, SCEsa, NEsko, TEskola, MFatkin, DFelix, SBFord, IFranco, OHGeelhoed, BGrewal, RPGudnason, VGuo, XGupta, NGustafsson, SGutmann, RHamsten, AHarris, TBHayward, CHeckbert, SRHernesniemi, JHocking, LJHofman, AHorimoto, ARVRHuang, JHuang, PLHuffman, JIngelsson, EIpek, EGIto, KJimenez-Conde, JJohnson, RJukema, JWKääb, SKähönen, MKamatani, YKane, JPKastrati, AKathiresan, SKatschnig-Winter, PKavousi, MKessler, TKietselaer, BLKirchhof, PKleber, MEKnight, SKrieger, JEKubo, MLauner, LJLaurikka, JLehtimäki, TLeineweber, KLemaitre, RNLi, MLim, HELin, HJLin, HLind, LLindgren, CMLokki, M-LLondon, BLoos, RJFLow, S-KLu, YLyytikäinen, L-PMacfarlane, PWMagnusson, PKMahajan, AMalik, RMansur, AJMarcus, GMMargolin, LMargulies, KBMärz, WMcManus, DDMelander, OMohanty, SMontgomery, JAMorley, MPMorris, APMüller-Nurasyid, MNatale, ANazarian, SNeumann, BNewton-Cheh, CNiemeijer, MNNikus, KNilsson, PNoordam, ROellers, HOlesen, MSOrho-Melander, MPadmanabhan, SPak, H-NParé, GPedersen, NLPera, JPereira, APorteous, DPsaty, BMPulit, SLPullinger, CRRader, DJRefsgaard, LRibasés, MRidker, PMRienstra, MRisch, LRoden, DMRosand, JRosenberg, MARost, NRotter, JISaba, SSandhu, RKSchnabel, RBSchramm, KSchunkert, HSchurman, CScott, SASeppälä, IShaffer, CShah, SShalaby, AAShim, JShoemaker, MBSiland, JESinisalo, JSinner, MFSlowik, ASmith, AVSmith, BHSmith, JGSmith, JDSmith, NLSoliman, EZSotoodehnia, NStricker, BHSun, ASun, HSvendsen, JHTanaka, TTanriverdi, KTaylor, KDTeder-Laving, MTeumer, AThériault, STrompet, STucker, NRTveit, AUitterlinden, AGVan Der Harst, PVan Gelder, ICVan Wagoner, DRVerweij, NVlachopoulou, EVölker, UWang, BWeeke, PEWeijs, BWeiss, RWeiss, SWells, QSWiggins, KLWong, JAWoo, DWorrall, BBYang, P-SYao, JYoneda, ZTZeller, TZeng, LLubitz, SALunetta, KLEllinor, PTAtrial fibrillation (AF) affects more than 33 million individuals worldwide1 and has a complex heritability2. We conducted the largest meta-analysis of genome-wide association studies (GWAS) for AF to date, consisting of more than half a million individuals, including 65,446 with AF. In total, we identified 97 loci significantly associated with AF, including 67 that were novel in a combined-ancestry analysis, and 3 that were novel in a European-specific analysis. We sought to identify AF-associated genes at the GWAS loci by performing RNA-sequencing and expression quantitative trait locus analyses in 101 left atrial samples, the most relevant tissue for AF. We also performed transcriptome-wide analyses that identified 57 AF-associated genes, 42 of which overlap with GWAS loci. The identified loci implicate genes enriched within cardiac developmental, electrophysiological, contractile and structural pathways. These results extend our understanding of the biological pathways underlying AF and may facilitate the development of therapeutics for AF. |
| spellingShingle | Roselli, C Chaffin, MD Weng, L-C Aeschbacher, S Ahlberg, G Albert, CM Almgren, P Alonso, A Anderson, CD Aragam, KG Arking, DE Barnard, J Bartz, TM Benjamin, EJ Bihlmeyer, NA Bis, JC Bloom, HL Boerwinkle, E Bottinger, EB Brody, JA Calkins, H Campbell, A Cappola, TP Carlquist, J Chasman, DI Chen, LY Chen, Y-DI Choi, E-K Choi, SH Christophersen, IE Chung, MK Cole, JW Conen, D Cook, J Crijns, HJ Cutler, MJ Damrauer, SM Daniels, BR Darbar, D Delgado, G Denny, JC Dichgans, M Dörr, M Dudink, EA Dudley, SC Esa, N Esko, T Eskola, M Fatkin, D Felix, SB Ford, I Franco, OH Geelhoed, B Grewal, RP Gudnason, V Guo, X Gupta, N Gustafsson, S Gutmann, R Hamsten, A Harris, TB Hayward, C Heckbert, SR Hernesniemi, J Hocking, LJ Hofman, A Horimoto, ARVR Huang, J Huang, PL Huffman, J Ingelsson, E Ipek, EG Ito, K Jimenez-Conde, J Johnson, R Jukema, JW Kääb, S Kähönen, M Kamatani, Y Kane, JP Kastrati, A Kathiresan, S Katschnig-Winter, P Kavousi, M Kessler, T Kietselaer, BL Kirchhof, P Kleber, ME Knight, S Krieger, JE Kubo, M Launer, LJ Laurikka, J Lehtimäki, T Leineweber, K Lemaitre, RN Li, M Lim, HE Lin, HJ Lin, H Lind, L Lindgren, CM Lokki, M-L London, B Loos, RJF Low, S-K Lu, Y Lyytikäinen, L-P Macfarlane, PW Magnusson, PK Mahajan, A Malik, R Mansur, AJ Marcus, GM Margolin, L Margulies, KB März, W McManus, DD Melander, O Mohanty, S Montgomery, JA Morley, MP Morris, AP Müller-Nurasyid, M Natale, A Nazarian, S Neumann, B Newton-Cheh, C Niemeijer, MN Nikus, K Nilsson, P Noordam, R Oellers, H Olesen, MS Orho-Melander, M Padmanabhan, S Pak, H-N Paré, G Pedersen, NL Pera, J Pereira, A Porteous, D Psaty, BM Pulit, SL Pullinger, CR Rader, DJ Refsgaard, L Ribasés, M Ridker, PM Rienstra, M Risch, L Roden, DM Rosand, J Rosenberg, MA Rost, N Rotter, JI Saba, S Sandhu, RK Schnabel, RB Schramm, K Schunkert, H Schurman, C Scott, SA Seppälä, I Shaffer, C Shah, S Shalaby, AA Shim, J Shoemaker, MB Siland, JE Sinisalo, J Sinner, MF Slowik, A Smith, AV Smith, BH Smith, JG Smith, JD Smith, NL Soliman, EZ Sotoodehnia, N Stricker, BH Sun, A Sun, H Svendsen, JH Tanaka, T Tanriverdi, K Taylor, KD Teder-Laving, M Teumer, A Thériault, S Trompet, S Tucker, NR Tveit, A Uitterlinden, AG Van Der Harst, P Van Gelder, IC Van Wagoner, DR Verweij, N Vlachopoulou, E Völker, U Wang, B Weeke, PE Weijs, B Weiss, R Weiss, S Wells, QS Wiggins, KL Wong, JA Woo, D Worrall, BB Yang, P-S Yao, J Yoneda, ZT Zeller, T Zeng, L Lubitz, SA Lunetta, KL Ellinor, PT Multi-ethnic genome-wide association study for atrial fibrillation |
| title | Multi-ethnic genome-wide association study for atrial fibrillation |
| title_full | Multi-ethnic genome-wide association study for atrial fibrillation |
| title_fullStr | Multi-ethnic genome-wide association study for atrial fibrillation |
| title_full_unstemmed | Multi-ethnic genome-wide association study for atrial fibrillation |
| title_short | Multi-ethnic genome-wide association study for atrial fibrillation |
| title_sort | multi ethnic genome wide association study for atrial fibrillation |
| work_keys_str_mv | AT rosellic multiethnicgenomewideassociationstudyforatrialfibrillation AT chaffinmd multiethnicgenomewideassociationstudyforatrialfibrillation AT wenglc multiethnicgenomewideassociationstudyforatrialfibrillation AT aeschbachers multiethnicgenomewideassociationstudyforatrialfibrillation AT ahlbergg multiethnicgenomewideassociationstudyforatrialfibrillation AT albertcm multiethnicgenomewideassociationstudyforatrialfibrillation AT almgrenp multiethnicgenomewideassociationstudyforatrialfibrillation AT alonsoa multiethnicgenomewideassociationstudyforatrialfibrillation AT andersoncd multiethnicgenomewideassociationstudyforatrialfibrillation AT aragamkg multiethnicgenomewideassociationstudyforatrialfibrillation AT arkingde multiethnicgenomewideassociationstudyforatrialfibrillation AT barnardj multiethnicgenomewideassociationstudyforatrialfibrillation AT bartztm multiethnicgenomewideassociationstudyforatrialfibrillation AT benjaminej multiethnicgenomewideassociationstudyforatrialfibrillation AT bihlmeyerna multiethnicgenomewideassociationstudyforatrialfibrillation AT bisjc multiethnicgenomewideassociationstudyforatrialfibrillation AT bloomhl multiethnicgenomewideassociationstudyforatrialfibrillation AT boerwinklee multiethnicgenomewideassociationstudyforatrialfibrillation AT bottingereb multiethnicgenomewideassociationstudyforatrialfibrillation AT brodyja multiethnicgenomewideassociationstudyforatrialfibrillation AT calkinsh multiethnicgenomewideassociationstudyforatrialfibrillation AT campbella multiethnicgenomewideassociationstudyforatrialfibrillation AT cappolatp multiethnicgenomewideassociationstudyforatrialfibrillation AT carlquistj multiethnicgenomewideassociationstudyforatrialfibrillation AT chasmandi multiethnicgenomewideassociationstudyforatrialfibrillation AT chenly multiethnicgenomewideassociationstudyforatrialfibrillation AT chenydi multiethnicgenomewideassociationstudyforatrialfibrillation AT choiek multiethnicgenomewideassociationstudyforatrialfibrillation AT choish multiethnicgenomewideassociationstudyforatrialfibrillation AT christophersenie multiethnicgenomewideassociationstudyforatrialfibrillation AT chungmk multiethnicgenomewideassociationstudyforatrialfibrillation AT colejw multiethnicgenomewideassociationstudyforatrialfibrillation AT conend multiethnicgenomewideassociationstudyforatrialfibrillation AT cookj multiethnicgenomewideassociationstudyforatrialfibrillation AT crijnshj multiethnicgenomewideassociationstudyforatrialfibrillation AT cutlermj multiethnicgenomewideassociationstudyforatrialfibrillation AT damrauersm multiethnicgenomewideassociationstudyforatrialfibrillation AT danielsbr multiethnicgenomewideassociationstudyforatrialfibrillation AT darbard multiethnicgenomewideassociationstudyforatrialfibrillation AT delgadog multiethnicgenomewideassociationstudyforatrialfibrillation AT dennyjc multiethnicgenomewideassociationstudyforatrialfibrillation AT dichgansm multiethnicgenomewideassociationstudyforatrialfibrillation AT dorrm multiethnicgenomewideassociationstudyforatrialfibrillation AT dudinkea multiethnicgenomewideassociationstudyforatrialfibrillation AT dudleysc multiethnicgenomewideassociationstudyforatrialfibrillation AT esan multiethnicgenomewideassociationstudyforatrialfibrillation AT eskot multiethnicgenomewideassociationstudyforatrialfibrillation AT eskolam multiethnicgenomewideassociationstudyforatrialfibrillation AT fatkind multiethnicgenomewideassociationstudyforatrialfibrillation AT felixsb multiethnicgenomewideassociationstudyforatrialfibrillation AT fordi multiethnicgenomewideassociationstudyforatrialfibrillation AT francooh multiethnicgenomewideassociationstudyforatrialfibrillation AT geelhoedb multiethnicgenomewideassociationstudyforatrialfibrillation AT grewalrp multiethnicgenomewideassociationstudyforatrialfibrillation AT gudnasonv multiethnicgenomewideassociationstudyforatrialfibrillation AT guox multiethnicgenomewideassociationstudyforatrialfibrillation AT guptan multiethnicgenomewideassociationstudyforatrialfibrillation AT gustafssons multiethnicgenomewideassociationstudyforatrialfibrillation AT gutmannr multiethnicgenomewideassociationstudyforatrialfibrillation AT hamstena multiethnicgenomewideassociationstudyforatrialfibrillation AT harristb multiethnicgenomewideassociationstudyforatrialfibrillation AT haywardc multiethnicgenomewideassociationstudyforatrialfibrillation AT heckbertsr multiethnicgenomewideassociationstudyforatrialfibrillation AT hernesniemij multiethnicgenomewideassociationstudyforatrialfibrillation AT hockinglj multiethnicgenomewideassociationstudyforatrialfibrillation AT hofmana multiethnicgenomewideassociationstudyforatrialfibrillation AT horimotoarvr multiethnicgenomewideassociationstudyforatrialfibrillation AT huangj multiethnicgenomewideassociationstudyforatrialfibrillation AT huangpl multiethnicgenomewideassociationstudyforatrialfibrillation AT huffmanj multiethnicgenomewideassociationstudyforatrialfibrillation AT ingelssone multiethnicgenomewideassociationstudyforatrialfibrillation AT ipekeg multiethnicgenomewideassociationstudyforatrialfibrillation AT itok multiethnicgenomewideassociationstudyforatrialfibrillation AT jimenezcondej multiethnicgenomewideassociationstudyforatrialfibrillation AT johnsonr multiethnicgenomewideassociationstudyforatrialfibrillation AT jukemajw multiethnicgenomewideassociationstudyforatrialfibrillation AT kaabs multiethnicgenomewideassociationstudyforatrialfibrillation AT kahonenm multiethnicgenomewideassociationstudyforatrialfibrillation AT kamataniy multiethnicgenomewideassociationstudyforatrialfibrillation AT kanejp multiethnicgenomewideassociationstudyforatrialfibrillation AT kastratia multiethnicgenomewideassociationstudyforatrialfibrillation AT kathiresans multiethnicgenomewideassociationstudyforatrialfibrillation AT katschnigwinterp multiethnicgenomewideassociationstudyforatrialfibrillation AT kavousim multiethnicgenomewideassociationstudyforatrialfibrillation AT kesslert multiethnicgenomewideassociationstudyforatrialfibrillation AT kietselaerbl multiethnicgenomewideassociationstudyforatrialfibrillation AT kirchhofp multiethnicgenomewideassociationstudyforatrialfibrillation AT kleberme multiethnicgenomewideassociationstudyforatrialfibrillation AT knights multiethnicgenomewideassociationstudyforatrialfibrillation AT kriegerje multiethnicgenomewideassociationstudyforatrialfibrillation AT kubom multiethnicgenomewideassociationstudyforatrialfibrillation AT launerlj multiethnicgenomewideassociationstudyforatrialfibrillation AT laurikkaj multiethnicgenomewideassociationstudyforatrialfibrillation AT lehtimakit multiethnicgenomewideassociationstudyforatrialfibrillation AT leineweberk multiethnicgenomewideassociationstudyforatrialfibrillation AT lemaitrern multiethnicgenomewideassociationstudyforatrialfibrillation AT lim multiethnicgenomewideassociationstudyforatrialfibrillation AT limhe multiethnicgenomewideassociationstudyforatrialfibrillation AT linhj multiethnicgenomewideassociationstudyforatrialfibrillation AT linh multiethnicgenomewideassociationstudyforatrialfibrillation AT lindl multiethnicgenomewideassociationstudyforatrialfibrillation AT lindgrencm multiethnicgenomewideassociationstudyforatrialfibrillation AT lokkiml multiethnicgenomewideassociationstudyforatrialfibrillation AT londonb multiethnicgenomewideassociationstudyforatrialfibrillation AT loosrjf multiethnicgenomewideassociationstudyforatrialfibrillation AT lowsk multiethnicgenomewideassociationstudyforatrialfibrillation AT luy multiethnicgenomewideassociationstudyforatrialfibrillation AT lyytikainenlp multiethnicgenomewideassociationstudyforatrialfibrillation AT macfarlanepw multiethnicgenomewideassociationstudyforatrialfibrillation AT magnussonpk multiethnicgenomewideassociationstudyforatrialfibrillation AT mahajana multiethnicgenomewideassociationstudyforatrialfibrillation AT malikr multiethnicgenomewideassociationstudyforatrialfibrillation AT mansuraj multiethnicgenomewideassociationstudyforatrialfibrillation AT marcusgm multiethnicgenomewideassociationstudyforatrialfibrillation AT margolinl multiethnicgenomewideassociationstudyforatrialfibrillation AT margulieskb multiethnicgenomewideassociationstudyforatrialfibrillation AT marzw multiethnicgenomewideassociationstudyforatrialfibrillation AT mcmanusdd multiethnicgenomewideassociationstudyforatrialfibrillation AT melandero multiethnicgenomewideassociationstudyforatrialfibrillation AT mohantys multiethnicgenomewideassociationstudyforatrialfibrillation AT montgomeryja multiethnicgenomewideassociationstudyforatrialfibrillation AT morleymp multiethnicgenomewideassociationstudyforatrialfibrillation AT morrisap multiethnicgenomewideassociationstudyforatrialfibrillation AT mullernurasyidm multiethnicgenomewideassociationstudyforatrialfibrillation AT natalea multiethnicgenomewideassociationstudyforatrialfibrillation AT nazarians multiethnicgenomewideassociationstudyforatrialfibrillation AT neumannb multiethnicgenomewideassociationstudyforatrialfibrillation AT newtonchehc multiethnicgenomewideassociationstudyforatrialfibrillation AT niemeijermn multiethnicgenomewideassociationstudyforatrialfibrillation AT nikusk multiethnicgenomewideassociationstudyforatrialfibrillation AT nilssonp multiethnicgenomewideassociationstudyforatrialfibrillation AT noordamr multiethnicgenomewideassociationstudyforatrialfibrillation AT oellersh multiethnicgenomewideassociationstudyforatrialfibrillation AT olesenms multiethnicgenomewideassociationstudyforatrialfibrillation AT orhomelanderm multiethnicgenomewideassociationstudyforatrialfibrillation AT padmanabhans multiethnicgenomewideassociationstudyforatrialfibrillation AT pakhn multiethnicgenomewideassociationstudyforatrialfibrillation AT pareg multiethnicgenomewideassociationstudyforatrialfibrillation AT pedersennl multiethnicgenomewideassociationstudyforatrialfibrillation AT peraj multiethnicgenomewideassociationstudyforatrialfibrillation AT pereiraa multiethnicgenomewideassociationstudyforatrialfibrillation AT porteousd multiethnicgenomewideassociationstudyforatrialfibrillation AT psatybm multiethnicgenomewideassociationstudyforatrialfibrillation AT pulitsl multiethnicgenomewideassociationstudyforatrialfibrillation AT pullingercr multiethnicgenomewideassociationstudyforatrialfibrillation AT raderdj multiethnicgenomewideassociationstudyforatrialfibrillation AT refsgaardl multiethnicgenomewideassociationstudyforatrialfibrillation AT ribasesm multiethnicgenomewideassociationstudyforatrialfibrillation AT ridkerpm multiethnicgenomewideassociationstudyforatrialfibrillation AT rienstram multiethnicgenomewideassociationstudyforatrialfibrillation AT rischl multiethnicgenomewideassociationstudyforatrialfibrillation AT rodendm multiethnicgenomewideassociationstudyforatrialfibrillation AT rosandj multiethnicgenomewideassociationstudyforatrialfibrillation AT rosenbergma multiethnicgenomewideassociationstudyforatrialfibrillation AT rostn multiethnicgenomewideassociationstudyforatrialfibrillation AT rotterji multiethnicgenomewideassociationstudyforatrialfibrillation AT sabas multiethnicgenomewideassociationstudyforatrialfibrillation AT sandhurk multiethnicgenomewideassociationstudyforatrialfibrillation AT schnabelrb multiethnicgenomewideassociationstudyforatrialfibrillation AT schrammk multiethnicgenomewideassociationstudyforatrialfibrillation AT schunkerth multiethnicgenomewideassociationstudyforatrialfibrillation AT schurmanc multiethnicgenomewideassociationstudyforatrialfibrillation AT scottsa multiethnicgenomewideassociationstudyforatrialfibrillation AT seppalai multiethnicgenomewideassociationstudyforatrialfibrillation AT shafferc multiethnicgenomewideassociationstudyforatrialfibrillation AT shahs multiethnicgenomewideassociationstudyforatrialfibrillation AT shalabyaa multiethnicgenomewideassociationstudyforatrialfibrillation AT shimj multiethnicgenomewideassociationstudyforatrialfibrillation AT shoemakermb multiethnicgenomewideassociationstudyforatrialfibrillation AT silandje multiethnicgenomewideassociationstudyforatrialfibrillation AT sinisaloj multiethnicgenomewideassociationstudyforatrialfibrillation AT sinnermf multiethnicgenomewideassociationstudyforatrialfibrillation AT slowika multiethnicgenomewideassociationstudyforatrialfibrillation AT smithav multiethnicgenomewideassociationstudyforatrialfibrillation AT smithbh multiethnicgenomewideassociationstudyforatrialfibrillation AT smithjg multiethnicgenomewideassociationstudyforatrialfibrillation AT smithjd multiethnicgenomewideassociationstudyforatrialfibrillation AT smithnl multiethnicgenomewideassociationstudyforatrialfibrillation AT solimanez multiethnicgenomewideassociationstudyforatrialfibrillation AT sotoodehnian multiethnicgenomewideassociationstudyforatrialfibrillation AT strickerbh multiethnicgenomewideassociationstudyforatrialfibrillation AT suna multiethnicgenomewideassociationstudyforatrialfibrillation AT sunh multiethnicgenomewideassociationstudyforatrialfibrillation AT svendsenjh multiethnicgenomewideassociationstudyforatrialfibrillation AT tanakat multiethnicgenomewideassociationstudyforatrialfibrillation AT tanriverdik multiethnicgenomewideassociationstudyforatrialfibrillation AT taylorkd multiethnicgenomewideassociationstudyforatrialfibrillation AT tederlavingm multiethnicgenomewideassociationstudyforatrialfibrillation AT teumera multiethnicgenomewideassociationstudyforatrialfibrillation AT theriaults multiethnicgenomewideassociationstudyforatrialfibrillation AT trompets multiethnicgenomewideassociationstudyforatrialfibrillation AT tuckernr multiethnicgenomewideassociationstudyforatrialfibrillation AT tveita multiethnicgenomewideassociationstudyforatrialfibrillation AT uitterlindenag multiethnicgenomewideassociationstudyforatrialfibrillation AT vanderharstp multiethnicgenomewideassociationstudyforatrialfibrillation AT vangelderic multiethnicgenomewideassociationstudyforatrialfibrillation AT vanwagonerdr multiethnicgenomewideassociationstudyforatrialfibrillation AT verweijn multiethnicgenomewideassociationstudyforatrialfibrillation AT vlachopouloue multiethnicgenomewideassociationstudyforatrialfibrillation AT volkeru multiethnicgenomewideassociationstudyforatrialfibrillation AT wangb multiethnicgenomewideassociationstudyforatrialfibrillation AT weekepe multiethnicgenomewideassociationstudyforatrialfibrillation AT weijsb multiethnicgenomewideassociationstudyforatrialfibrillation AT weissr multiethnicgenomewideassociationstudyforatrialfibrillation AT weisss multiethnicgenomewideassociationstudyforatrialfibrillation AT wellsqs multiethnicgenomewideassociationstudyforatrialfibrillation AT wigginskl multiethnicgenomewideassociationstudyforatrialfibrillation AT wongja multiethnicgenomewideassociationstudyforatrialfibrillation AT wood multiethnicgenomewideassociationstudyforatrialfibrillation AT worrallbb multiethnicgenomewideassociationstudyforatrialfibrillation AT yangps multiethnicgenomewideassociationstudyforatrialfibrillation AT yaoj multiethnicgenomewideassociationstudyforatrialfibrillation AT yonedazt multiethnicgenomewideassociationstudyforatrialfibrillation AT zellert multiethnicgenomewideassociationstudyforatrialfibrillation AT zengl multiethnicgenomewideassociationstudyforatrialfibrillation AT lubitzsa multiethnicgenomewideassociationstudyforatrialfibrillation AT lunettakl multiethnicgenomewideassociationstudyforatrialfibrillation AT ellinorpt multiethnicgenomewideassociationstudyforatrialfibrillation |