GATA1s induces hyperproliferation of eosinophil precursors in Down syndrome transient leukemia.

GATA1s induces hyperproliferation of eosinophil precursors in Down syndrome transient leukemia.

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Transient leukemia (TL) is evident in 5-10% of all neonates with Down syndrome (DS) and associated with N-terminal truncating GATA1 mutations (GATA1s). Here we report that TL-cell clones generate abundant eosinophils in a substantial fraction of patients. Sorted eosinophils from patients with TL and...

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Bibliographic Details
Main Authors:	Maroz, A, Stachorski, L, Emmrich, S, Reinhardt, K, Xu, J, Shao, Z, Käbler, S, Dertmann, T, Hitzler, J, Roberts, I, Vyas, P, Juban, G, Hennig, C, Hansen, G, Li, Z, Orkin, S, Reinhardt, D, Klusmann, J
Format:	Journal article
Language:	English
Published:	2014

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