GATA1s induces hyperproliferation of eosinophil precursors in Down syndrome transient leukemia.

Transient leukemia (TL) is evident in 5-10% of all neonates with Down syndrome (DS) and associated with N-terminal truncating GATA1 mutations (GATA1s). Here we report that TL-cell clones generate abundant eosinophils in a substantial fraction of patients. Sorted eosinophils from patients with TL and...

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Hauptverfasser:	Maroz, A, Stachorski, L, Emmrich, S, Reinhardt, K, Xu, J, Shao, Z, Käbler, S, Dertmann, T, Hitzler, J, Roberts, I, Vyas, P, Juban, G, Hennig, C, Hansen, G, Li, Z, Orkin, S, Reinhardt, D, Klusmann, J
Format:	Journal article
Sprache:	English
Veröffentlicht:	2014

GATA1s induces hyperproliferation of eosinophil precursors in Down syndrome transient leukemia von Maroz, A, Stachorski, L, Emmrich, S, Reinhardt, K, Xu, J, Shao, Z, Käbler, S, Dertmann, T, Hitzler, J, Roberts, I, Vyas, P, Juban, G, Hennig, C, Hansen, G, Li, Z, Orkin, S, Reinhardt, D, Klusmann, J

Veröffentlicht 2014

Journal article

GATA1s induces hyperproliferation of eosinophil precursors in Down syndrome transient leukemia.

GATA1s induces hyperproliferation of eosinophil precursors in Down syndrome transient leukemia von Maroz, A, Stachorski, L, Emmrich, S, Reinhardt, K, Xu, J, Shao, Z, Käbler, S, Dertmann, T, Hitzler, J, Roberts, I, Vyas, P, Juban, G, Hennig, C, Hansen, G, Li, Z, Orkin, S, Reinhardt, D, Klusmann, J

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