Co-transcriptional RNA cleavage provides a failsafe termination mechanism for yeast RNA polymerase I.

Ribosomal RNA, transcribed by RNA polymerase (Pol) I, accounts for most cellular RNA. Since Pol I transcribes rDNA repeats with high processivity and polymerase density, transcription termination is a critical process. Early in vitro studies proposed polymerase pausing by Reb1 and transcript release...

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Những tác giả chính: Braglia, P, Kawauchi, J, Proudfoot, N
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: Oxford University Press 2011