Is a controlled trial of long-term oral anticoagulants in patients with stroke and non-rheumatic atrial fibrillation worthwhile?

A controlled randomised trial large enough to assess the value of anticoagulating stroke patients in atrial fibrillation would be difficult to conduct in the UK and the results would be applicable to only a small proportion of stroke patients. It would be more worthwhile to organise a trial that als...

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Главные авторы: Sandercock, P, Warlow, C, Bamford, J, Peto, R, Starkey, I
Формат: Journal article
Язык:English
Опубликовано: 1986
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author Sandercock, P
Warlow, C
Bamford, J
Peto, R
Starkey, I
author_facet Sandercock, P
Warlow, C
Bamford, J
Peto, R
Starkey, I
author_sort Sandercock, P
collection OXFORD
description A controlled randomised trial large enough to assess the value of anticoagulating stroke patients in atrial fibrillation would be difficult to conduct in the UK and the results would be applicable to only a small proportion of stroke patients. It would be more worthwhile to organise a trial that also assessed the value of other treatments that are simpler and applicable to all stroke patients. A trial that assessed the value of aspirin and beta-blockers against control in all stroke patients would not cost much more than one restricted to comparing anticoagulants against control in patients with stroke and atrial fibrillation but would provide information of more relevance to the management of patients with stroke in the UK.
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spelling oxford-uuid:a6379d50-4724-404c-9e67-945e75aa4fb22022-03-27T02:45:41ZIs a controlled trial of long-term oral anticoagulants in patients with stroke and non-rheumatic atrial fibrillation worthwhile?Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a6379d50-4724-404c-9e67-945e75aa4fb2EnglishSymplectic Elements at Oxford1986Sandercock, PWarlow, CBamford, JPeto, RStarkey, IA controlled randomised trial large enough to assess the value of anticoagulating stroke patients in atrial fibrillation would be difficult to conduct in the UK and the results would be applicable to only a small proportion of stroke patients. It would be more worthwhile to organise a trial that also assessed the value of other treatments that are simpler and applicable to all stroke patients. A trial that assessed the value of aspirin and beta-blockers against control in all stroke patients would not cost much more than one restricted to comparing anticoagulants against control in patients with stroke and atrial fibrillation but would provide information of more relevance to the management of patients with stroke in the UK.
spellingShingle Sandercock, P
Warlow, C
Bamford, J
Peto, R
Starkey, I
Is a controlled trial of long-term oral anticoagulants in patients with stroke and non-rheumatic atrial fibrillation worthwhile?
title Is a controlled trial of long-term oral anticoagulants in patients with stroke and non-rheumatic atrial fibrillation worthwhile?
title_full Is a controlled trial of long-term oral anticoagulants in patients with stroke and non-rheumatic atrial fibrillation worthwhile?
title_fullStr Is a controlled trial of long-term oral anticoagulants in patients with stroke and non-rheumatic atrial fibrillation worthwhile?
title_full_unstemmed Is a controlled trial of long-term oral anticoagulants in patients with stroke and non-rheumatic atrial fibrillation worthwhile?
title_short Is a controlled trial of long-term oral anticoagulants in patients with stroke and non-rheumatic atrial fibrillation worthwhile?
title_sort is a controlled trial of long term oral anticoagulants in patients with stroke and non rheumatic atrial fibrillation worthwhile
work_keys_str_mv AT sandercockp isacontrolledtrialoflongtermoralanticoagulantsinpatientswithstrokeandnonrheumaticatrialfibrillationworthwhile
AT warlowc isacontrolledtrialoflongtermoralanticoagulantsinpatientswithstrokeandnonrheumaticatrialfibrillationworthwhile
AT bamfordj isacontrolledtrialoflongtermoralanticoagulantsinpatientswithstrokeandnonrheumaticatrialfibrillationworthwhile
AT petor isacontrolledtrialoflongtermoralanticoagulantsinpatientswithstrokeandnonrheumaticatrialfibrillationworthwhile
AT starkeyi isacontrolledtrialoflongtermoralanticoagulantsinpatientswithstrokeandnonrheumaticatrialfibrillationworthwhile