A conditional model of MLL-AF4 B-cell tumourigenesis using invertor technology.

A conditional model of MLL-AF4 B-cell tumourigenesis using invertor technology.

MLL-AF4 fusion is the most common consequence of chromosomal translocations in infant leukaemia and is associated with a poor prognosis. MLL-AF4 is thought to be required in haematopoietic stem cells to elicit leukaemia and may be involved in tumour phenotype specification as it is only found in B-c...

Bibliográfalaš dieđut
Váldodahkkit:	Metzler, M, Forster, A, Pannell, R, Arends, M, Daser, A, Lobato, M, Rabbitts, T
Materiálatiipa:	Journal article
Giella:	English
Almmustuhtton:	2006

Geahča maid

Inter-chromosomal recombination of Mll and Af9 genes mediated by cre-loxP in mouse development.
Dahkki: Collins, E, et al.
Almmustuhtton: (2000)

Extending the repertoire of the mixed-lineage leukemia gene MLL in leukemogenesis.
Dahkki: Daser, A, et al.
Almmustuhtton: (2004)

Engineering de novo reciprocal chromosomal translocations associated with Mll to replicate primary events of human cancer.
Dahkki: Forster, A, et al.
Almmustuhtton: (2003)

Modeling chromosomal translocations using conditional alleles to recapitulate initiating events in human leukemias.
Dahkki: Lobato, M, et al.
Almmustuhtton: (2008)

The versatile mixed lineage leukaemia gene MLL and its many associations in leukaemogenesis.
Dahkki: Daser, A, et al.
Almmustuhtton: (2005)

Mouse Af9 is a controller of embryo patterning, like Mll, whose human homologue fuses with Af9 after chromosomal translocation in leukemia.
Dahkki: Collins, E, et al.
Almmustuhtton: (2002)

Mll fusions generated by Cre-loxP-mediated de novo translocations can induce lineage reassignment in tumorigenesis.
Dahkki: Drynan, L, et al.
Almmustuhtton: (2005)

The Ews-ERG fusion protein can initiate neoplasia from lineage-committed haematopoietic cells
Dahkki: Codrington, R, et al.
Almmustuhtton: (2005)

The role of DOT1L in MLL-AF4 leukaemia
Dahkki: Godfrey, L
Almmustuhtton: (2018)

The function of PRC2 in MLL-AF4 acute lymphoid leukaemia
Dahkki: Tapia, M
Almmustuhtton: (2015)

The role of MYB in MLL-AF9 leukaemia
Dahkki: Lau, IJ
Almmustuhtton: (2019)

Tumorigenesis in mice with a fusion of the leukaemia oncogene Mll and the bacterial lacZ gene.
Dahkki: Dobson, C, et al.
Almmustuhtton: (2000)

Static-invertor power supplies /
Dahkki: 441610 Tanzer, R. P. E.

MLL gene fusions in human leukaemias: in vivo modelling to recapitulate these primary tumourigenic events.
Dahkki: Rodriguez-Perales, S, et al.
Almmustuhtton: (2008)

PAF1 and FACT cooperate with MLL-AF4 to drive enhancer activity in leukemia
Dahkki: Milne, T, et al.
Almmustuhtton: (2022)

Static invertors for A.C. power supplies /
Dahkki: 429937 Start, J. D. M.

Leukaemia lineage specification caused by cell-specific Mll-Enl translocations.
Dahkki: Cano, F, et al.
Almmustuhtton: (2008)

MLL-AF4 cooperates with PAF1 and FACT to drive high-density enhancer interactions in leukemia
Dahkki: Crump, NT, et al.
Almmustuhtton: (2023)

Chromosomal translocation engineering to recapitulate primary events of human cancer.
Dahkki: Forster, A, et al.
Almmustuhtton: (2005)

RUNX1 is a key target in t(4;11) leukemias that contributes to gene activation through an AF4-MLL complex interaction.
Dahkki: Wilkinson, A, et al.
Almmustuhtton: (2013)

RUNX1 Is a Key Target in t(4;11) Leukemias that Contributes to Gene Activation through an AF4-MLL Complex Interaction
Dahkki: Wilkinson, A, et al.
Almmustuhtton: (2013)

Machine learning methods for next generation sequencing data: applications to MLL-AF4 leukemia and demographic inference
Dahkki: Cole, CB
Almmustuhtton: (2021)

MLL-AF4 binds directly to a BCL-2 specific enhancer and modulates H3K27 acetylation.
Dahkki: Godfrey, L, et al.
Almmustuhtton: (2016)

Distinct pathways regulated by menin and by MLL1 in hematopoietic stem cells and developing B cells.
Dahkki: Li, B, et al.
Almmustuhtton: (2013)

MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia.
Dahkki: Kerry, J, et al.
Almmustuhtton: (2017)

Next generation sequencing techniques reveal molecular mechanisms of MYB regulation and function in MLL-AF9 Leukemia
Dahkki: Lau, I, et al.
Almmustuhtton: (2017)

Developmentally regulated molecular programmes in human fetal haematopoietic cells cooperate with MLL-AF4 to drive infant acute lymphoblastic leukaemia
Dahkki: Rice, S
Almmustuhtton: (2021)

A novel mutation in the miR-128b gene reduces miRNA processing and leads to glucocorticoid resistance of MLL-AF4 Acute Lymphocytic Leukemia cells
Dahkki: Kotani, Ai, et al.
Almmustuhtton: (2012)

Cyclins and their related proteins in pituitary tumourigenesis.
Dahkki: Muşat, M, et al.
Almmustuhtton: (2010)

The promiscuous MLL gene links chromosomal translocations to cellular differentiation and tumour tropism.
Dahkki: Collins, E, et al.
Almmustuhtton: (2002)

Intracellular antibody capture technology: application to selection of intracellular antibodies recognising the BCR-ABL oncogenic protein.
Dahkki: Tse, E, et al.
Almmustuhtton: (2002)

The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia
Dahkki: Numata, A, et al.
Almmustuhtton: (2018)

CDC4/FBXW7 and the 'just enough' model of tumourigenesis
Dahkki: Davis, H, et al.
Almmustuhtton: (2012)

CDC4/FBXW7 and the 'just enough' model of tumourigenesis.
Dahkki: Davis, H, et al.
Almmustuhtton: (2012)

Erratum: Interrogation of genomes by molecular copy-number counting (MCC) (Nature Methods (2006) vol. 3 (447-453))
Dahkki: Daser, A, et al.
Almmustuhtton: (2006)

Interrogation of genomes by molecular copy-number counting (MCC).
Dahkki: Daser, A, et al.
Almmustuhtton: (2006)

A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program
Dahkki: Rice, S, et al.
Almmustuhtton: (2021)

Investigation of the role of ASPP2 in tumourigenesis
Dahkki: Tordella, L
Almmustuhtton: (2012)

De novo production of diverse intracellular antibody libraries.
Dahkki: Tanaka, T, et al.
Almmustuhtton: (2003)

Preclinical modeling of cytosine arabinoside response in Mll-Enl translocator mouse leukemias.
Dahkki: Cano, F, et al.
Almmustuhtton: (2008)