Discovery of a selective inhibitor for the YEATS domains of ENL/AF9

Discovery of a selective inhibitor for the YEATS domains of ENL/AF9

Eleven-nineteen leukemia (ENL) contains an epigenetic reader domain (YEATS domain) that recognizes lysine acylation on histone 3 and facilitates transcription initiation and elongation through its interactions with the super elongation complex (SEC) and the histone methyl transferase DOT1L. Although...

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Bibliographic Details
Main Authors: Christott, T, Bennett, J, Coxon, C, Monteiro, O, Giroud, C, Beke, V, Felce, S, Gamble, V, Gileadi, C, Poda, G, Al-Awar, R, Farnie, G, Fedorov, O
Format: Journal article
Language:English
Published: SAGE Publications 2018

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