Carbohydrate and fat have different effects on plasma leptin concentrations and adipose tissue leptin production.
Leptin is secreted by adipocytes and plays a role in the regulation of food intake. However, the regulation of leptin production by adipose tissue is unclear. We have investigated whether a mixed meal or a high-fat load given orally, or a pure fat load given intravenously, stimulates adipose tissue...
| Main Authors: | , , |
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| Formato: | Journal article |
| Idioma: | English |
| Publicado: |
2001
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| _version_ | 1826289452760170496 |
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| author | Evans, K Clark, M Frayn, K |
| author_facet | Evans, K Clark, M Frayn, K |
| author_sort | Evans, K |
| collection | OXFORD |
| description | Leptin is secreted by adipocytes and plays a role in the regulation of food intake. However, the regulation of leptin production by adipose tissue is unclear. We have investigated whether a mixed meal or a high-fat load given orally, or a pure fat load given intravenously, stimulates adipose tissue leptin production. Six volunteers were studied on two occasions following an overnight fast. On one occasion they consumed tomato soup containing 40 g of triacylglycerol (as Intralipid) and 9.6 g of carbohydrate; on the other occasion Intralipid was infused intravenously over 4 h to give the same fat load. A further eight subjects consumed a mixed meal (containing 37 g of fat and 100 g of carbohydrate) after an overnight fast. Paired blood samples were obtained from an arterialized hand vein and a vein draining subcutaneous adipose tissue at baseline and for 6 h following the meals or the start of the infusion. After both the intravenous and oral fat loads, the arterialized and adipose venous plasma leptin concentrations decreased over 6 h (both P<0.001), as did the leptin veno--arterial difference (P=0.01). Following the mixed meal, there was a slight increase in the arterialized plasma leptin concentration (P=0.02) and a more marked increase in the adipose venous plasma leptin concentration (P=0.03) and in the adipose tissue leptin veno--arterial difference (P=0.01), all peaking at 240 min. We conclude that the increase in plasma leptin concentration observed after meals is not simply a result of an energy load, but is in response to a signal that is not present following a fat load without carbohydrate. |
| first_indexed | 2024-03-07T02:29:06Z |
| format | Journal article |
| id | oxford-uuid:a6a126a6-26b2-436b-8ca1-2ce31f4f1730 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:29:06Z |
| publishDate | 2001 |
| record_format | dspace |
| spelling | oxford-uuid:a6a126a6-26b2-436b-8ca1-2ce31f4f17302022-03-27T02:48:36ZCarbohydrate and fat have different effects on plasma leptin concentrations and adipose tissue leptin production.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a6a126a6-26b2-436b-8ca1-2ce31f4f1730EnglishSymplectic Elements at Oxford2001Evans, KClark, MFrayn, KLeptin is secreted by adipocytes and plays a role in the regulation of food intake. However, the regulation of leptin production by adipose tissue is unclear. We have investigated whether a mixed meal or a high-fat load given orally, or a pure fat load given intravenously, stimulates adipose tissue leptin production. Six volunteers were studied on two occasions following an overnight fast. On one occasion they consumed tomato soup containing 40 g of triacylglycerol (as Intralipid) and 9.6 g of carbohydrate; on the other occasion Intralipid was infused intravenously over 4 h to give the same fat load. A further eight subjects consumed a mixed meal (containing 37 g of fat and 100 g of carbohydrate) after an overnight fast. Paired blood samples were obtained from an arterialized hand vein and a vein draining subcutaneous adipose tissue at baseline and for 6 h following the meals or the start of the infusion. After both the intravenous and oral fat loads, the arterialized and adipose venous plasma leptin concentrations decreased over 6 h (both P<0.001), as did the leptin veno--arterial difference (P=0.01). Following the mixed meal, there was a slight increase in the arterialized plasma leptin concentration (P=0.02) and a more marked increase in the adipose venous plasma leptin concentration (P=0.03) and in the adipose tissue leptin veno--arterial difference (P=0.01), all peaking at 240 min. We conclude that the increase in plasma leptin concentration observed after meals is not simply a result of an energy load, but is in response to a signal that is not present following a fat load without carbohydrate. |
| spellingShingle | Evans, K Clark, M Frayn, K Carbohydrate and fat have different effects on plasma leptin concentrations and adipose tissue leptin production. |
| title | Carbohydrate and fat have different effects on plasma leptin concentrations and adipose tissue leptin production. |
| title_full | Carbohydrate and fat have different effects on plasma leptin concentrations and adipose tissue leptin production. |
| title_fullStr | Carbohydrate and fat have different effects on plasma leptin concentrations and adipose tissue leptin production. |
| title_full_unstemmed | Carbohydrate and fat have different effects on plasma leptin concentrations and adipose tissue leptin production. |
| title_short | Carbohydrate and fat have different effects on plasma leptin concentrations and adipose tissue leptin production. |
| title_sort | carbohydrate and fat have different effects on plasma leptin concentrations and adipose tissue leptin production |
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