Dipeptidyl peptidase IV inhibitors as novel regulators of vascular disease
Dipeptidyl peptidase IV (DPP-IV) has been revealed as an adipokine with potential relevance in cardiovascular disease (CVD), while clinically used DPP-IV inhibitors have demonstrated beneficial cardiovascular effects in several experimental studies. Perivascular adipose tissue (PVAT) is a unique adi...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Elsevier
2017
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| _version_ | 1797086966436593664 |
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| author | Akoumianakis, I Antoniades, C |
| author_facet | Akoumianakis, I Antoniades, C |
| author_sort | Akoumianakis, I |
| collection | OXFORD |
| description | Dipeptidyl peptidase IV (DPP-IV) has been revealed as an adipokine with potential relevance in cardiovascular disease (CVD), while clinically used DPP-IV inhibitors have demonstrated beneficial cardiovascular effects in several experimental studies. Perivascular adipose tissue (PVAT) is a unique adipose tissue depot in close anatomical proximity and bidirectional functional interaction with the vascular wall, which is a source of DPP-IV and its biology may be influenced by DPP-IV inhibition. Recently, DPP-IV inhibition has been associated with decreased local inflammation and oxidative stress both in the vascular wall and the PVAT, potentially regulating atherogenesis progression in vivo. DPP-IV inhibition may thus be a promising target in cardiovascular disease. However, the exact pleiotropic mechanisms that underlie the cardiovascular effects of DPP-IV inhibition need to be clarified, while the in vivo benefit of DPP-IV inhibition in humans remains unclear. |
| first_indexed | 2024-03-07T02:29:24Z |
| format | Journal article |
| id | oxford-uuid:a6b83ba7-b817-4476-a5d7-6c4652cd8c2e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:29:24Z |
| publishDate | 2017 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:a6b83ba7-b817-4476-a5d7-6c4652cd8c2e2022-03-27T02:49:19ZDipeptidyl peptidase IV inhibitors as novel regulators of vascular diseaseJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a6b83ba7-b817-4476-a5d7-6c4652cd8c2eEnglishSymplectic Elements at OxfordElsevier2017Akoumianakis, IAntoniades, CDipeptidyl peptidase IV (DPP-IV) has been revealed as an adipokine with potential relevance in cardiovascular disease (CVD), while clinically used DPP-IV inhibitors have demonstrated beneficial cardiovascular effects in several experimental studies. Perivascular adipose tissue (PVAT) is a unique adipose tissue depot in close anatomical proximity and bidirectional functional interaction with the vascular wall, which is a source of DPP-IV and its biology may be influenced by DPP-IV inhibition. Recently, DPP-IV inhibition has been associated with decreased local inflammation and oxidative stress both in the vascular wall and the PVAT, potentially regulating atherogenesis progression in vivo. DPP-IV inhibition may thus be a promising target in cardiovascular disease. However, the exact pleiotropic mechanisms that underlie the cardiovascular effects of DPP-IV inhibition need to be clarified, while the in vivo benefit of DPP-IV inhibition in humans remains unclear. |
| spellingShingle | Akoumianakis, I Antoniades, C Dipeptidyl peptidase IV inhibitors as novel regulators of vascular disease |
| title | Dipeptidyl peptidase IV inhibitors as novel regulators of vascular disease |
| title_full | Dipeptidyl peptidase IV inhibitors as novel regulators of vascular disease |
| title_fullStr | Dipeptidyl peptidase IV inhibitors as novel regulators of vascular disease |
| title_full_unstemmed | Dipeptidyl peptidase IV inhibitors as novel regulators of vascular disease |
| title_short | Dipeptidyl peptidase IV inhibitors as novel regulators of vascular disease |
| title_sort | dipeptidyl peptidase iv inhibitors as novel regulators of vascular disease |
| work_keys_str_mv | AT akoumianakisi dipeptidylpeptidaseivinhibitorsasnovelregulatorsofvasculardisease AT antoniadesc dipeptidylpeptidaseivinhibitorsasnovelregulatorsofvasculardisease |