Meiotic prophase requires proteolysis of M phase regulators mediated by the meiosis-specific APC/CAma1.
Whereas proliferating cells enter M phase shortly after DNA replication, the first M phase of meiosis is preceded by an extended prophase in which homologous chromosomes undergo recombination. Exit from prophase I is controlled by the recombination checkpoint (RC), which, in yeast, represses the mei...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2012
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| _version_ | 1826289507774758912 |
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| author | Okaz, E Argüello-Miranda, O Bogdanova, A Vinod, P Lipp, J Markova, Z Zagoriy, I Novak, B Zachariae, W |
| author_facet | Okaz, E Argüello-Miranda, O Bogdanova, A Vinod, P Lipp, J Markova, Z Zagoriy, I Novak, B Zachariae, W |
| author_sort | Okaz, E |
| collection | OXFORD |
| description | Whereas proliferating cells enter M phase shortly after DNA replication, the first M phase of meiosis is preceded by an extended prophase in which homologous chromosomes undergo recombination. Exit from prophase I is controlled by the recombination checkpoint (RC), which, in yeast, represses the meiosis-specific transcription factor Ndt80 required for the expression of B-type cyclins and other M phase regulators. We show that an extended prophase I additionally requires the suppression of latent, mitotic cell-cycle controls by the anaphase-promoting complex (APC/C) and its meiosis-specific activator Ama1, which trigger the degradation of M phase regulators and Ndd1, a subunit of a mitotic transcription factor. ama1Δ mutants exit from prophase I prematurely and independently of the RC, which results in recombination defects and chromosome missegregation. Thus, control of prophase I by meiotic mechanisms depends on the suppression of the alternative, mitotic mechanisms by a meiosis-specific form of the APC/C. |
| first_indexed | 2024-03-07T02:29:56Z |
| format | Journal article |
| id | oxford-uuid:a6e3a19c-073e-419f-869c-c7d7914300b9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:29:56Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:a6e3a19c-073e-419f-869c-c7d7914300b92022-03-27T02:50:38ZMeiotic prophase requires proteolysis of M phase regulators mediated by the meiosis-specific APC/CAma1.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a6e3a19c-073e-419f-869c-c7d7914300b9EnglishSymplectic Elements at Oxford2012Okaz, EArgüello-Miranda, OBogdanova, AVinod, PLipp, JMarkova, ZZagoriy, INovak, BZachariae, WWhereas proliferating cells enter M phase shortly after DNA replication, the first M phase of meiosis is preceded by an extended prophase in which homologous chromosomes undergo recombination. Exit from prophase I is controlled by the recombination checkpoint (RC), which, in yeast, represses the meiosis-specific transcription factor Ndt80 required for the expression of B-type cyclins and other M phase regulators. We show that an extended prophase I additionally requires the suppression of latent, mitotic cell-cycle controls by the anaphase-promoting complex (APC/C) and its meiosis-specific activator Ama1, which trigger the degradation of M phase regulators and Ndd1, a subunit of a mitotic transcription factor. ama1Δ mutants exit from prophase I prematurely and independently of the RC, which results in recombination defects and chromosome missegregation. Thus, control of prophase I by meiotic mechanisms depends on the suppression of the alternative, mitotic mechanisms by a meiosis-specific form of the APC/C. |
| spellingShingle | Okaz, E Argüello-Miranda, O Bogdanova, A Vinod, P Lipp, J Markova, Z Zagoriy, I Novak, B Zachariae, W Meiotic prophase requires proteolysis of M phase regulators mediated by the meiosis-specific APC/CAma1. |
| title | Meiotic prophase requires proteolysis of M phase regulators mediated by the meiosis-specific APC/CAma1. |
| title_full | Meiotic prophase requires proteolysis of M phase regulators mediated by the meiosis-specific APC/CAma1. |
| title_fullStr | Meiotic prophase requires proteolysis of M phase regulators mediated by the meiosis-specific APC/CAma1. |
| title_full_unstemmed | Meiotic prophase requires proteolysis of M phase regulators mediated by the meiosis-specific APC/CAma1. |
| title_short | Meiotic prophase requires proteolysis of M phase regulators mediated by the meiosis-specific APC/CAma1. |
| title_sort | meiotic prophase requires proteolysis of m phase regulators mediated by the meiosis specific apc cama1 |
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